Objective: This study aims to investigate the correlation between the imaging characteristics of patients with IgG4-related ophthalmic disease (IgG4-ROD) and the serum immunoglobulin G4 (IgG4) levels, providing new insights for assessing the systemic severity of IgG4-related diseases. Methods We collected postoperative tissue samples from 29 patients with histopathologically confirmed IgG4-ROD at the Ophthalmology Department of Jilin University Second Hospital from August 2023 to September 2024. We retrospectively analyzed the correlation between patients' orbital imaging features and serum IgG4 levels, and explored the proportion of characteristic imaging changes including enlargement of the lacrimal gland, thickening of the trigeminal nerve branches, thickening of the extraocular muscles, inflammatory-like changes of the nasal mucous membranes, hypertrophy of the eyelid soft tissues, as well as hyperplasia of other intraorbital soft tissues in the imaging. A grading score for affected tissue structures was established to evaluate the correlation between characteristic imaging changes and serum IgG4 levels. Results Among the 29 patients diagnosed with IgG4-ROD, lacrimal gland involvement was observed in all patients (100%). Extraocular muscle involvement was present in 17 patients (58.62%). Five patients had involvement of the trigeminal nerve branches (including 4 with infraorbital nerve involvement and 3 with frontal nerve involvement, with 2 patients having simultaneous involvement of both nerves), accounting for 17.24% of the cases. Eyelid soft tissue hypertrophy was observed in 24 patients (82.76%), and nasal mucosal inflammatory responses were noted in 15 patients (51.72%). Additionally, two patients (6.90%) presented with other proliferative lesions within the orbit. The correlation analysis between the grading scores for imaging features and serum IgG4 levels demonstrated a significant positive correlation. Conclusion The extent of characteristic structural involvement observed in the imaging features of IgG4-related ophthalmic disease is significantly correlated with serum IgG4 levels. This correlation can assist in evaluating the systemic severity of IgG4-related diseases and provides clinical evidence supporting the need for comprehensive systemic evaluations, such as PET-CT, in patients whose initial presentation is IgG4-related ophthalmic disease.

Objective: To analyze the main pathogenic bacteria and drug sensitivity of neonatal dacryocystitis. Method: 150 newborns with dacryocystitis between September 2020 and September 2024 were selected as sample cases, and samples were collected for testing to analyze their pathogenic bacteria and drug sensitivity. Result: There were 108 strains of pathogenic bacteria detected, with Gram positive bacteria accounting for 66.67% and Gram negative bacteria accounting for 33.33%; Positive bacteria are highly sensitive to vancomycin, ciprofloxacin, and tigecycline drugs; Negative bacteria are more sensitive to amikacin and imipenem. Conclusion: By understanding the main pathogenic bacteria and drug sensitivity of diseases, better therapeutic drugs can be selected in clinical treatment to accelerate the recovery of children.

Objective To determine the prevalence and risk factors of diabetic retinopathy (DR) among people with diabetes in Changji, Xinjiang. Methods From January to February 2019, 2242 patients with confirmed diabetes were collected in Changji. General information was obtained, height and weight were measured, and retinal photographs of both eyes were collected. Caculating the prevalence of DR, the risk factors of DR was analyzed by logistic regression model. Results (1) Among the 2,242 subjects, 2080 had graded binocular images, 8 had type I diabetes, and 2072 had type 2 diabetes, including 971 males and 1109 females. The prevalence of DR was 21.9% in 455 DR patients. The prevalence of Sight-Threatening Diabetic Retinopathy (STDR) in 227 patients was 10.9%.Background diabetic retinopathy in 335 patients, accounting for 16.8%;there were 36 cases (1.8%) of proliferative prediabetic retinopathy, proliferative diabetic retinopathy was observed in 84 patients (4.0%), There were 137 patients with macular edema, accounting for 6.6%.(2)Compared with the DR group, the non-DR group had statistically significant differences in "family history", "course of diabetes", "fasting fingertip blood glucose", "hypertension" and "insulin treatment" (P < 0.05).Binary Logistic regression analysis showed that "fasting glucose in fingertips", "course of diabetes", "family history" and "insulin treatment" were independent risk factors for the occurrence of DR. "Fingertip fasting glucose", "diabetic course", "insulin treatment", "hypertension" and "blood glucose monitoring" are independent risk factors affecting the occurrence of STDR. Conclusions The prevalence of DR in Changji was 21.9%. The course of diabetes, fasting glucose in fingertips and insulin treatment are independent risk factors for DR. We should pay attention to these risk factors, timely intervention, reduce visual loss.

Lacrimal disorders are a common ophthalmic disease characterized by a complex diagnosis and treatment process, involving intricate treatment methods and multiple clinical and image data. Previous studies have indicated that artificial intelligence (AI), particularly in the fields of machine learning and deep learning, has significant potential for application in the diagnosis and treatment of lacrimal disorders. However, the application of AI in this filed still faces numerous challenges, including the intricacies of multimodal data integration, constraints in model generalisation capabilities, the necessity for real-time predictions and adaptive adjustments, and the challenges associated with clinical validation. These issues require further research and resolution. This paper summarizes the current status and challenges of AI applications in the diagnosis and treatment of lacrimal disorders, explores emerging technologies and strategies, and proposes future development directions, with a special emphasis on the importance of integrating AI with emerging technologies. Through forward-looking analysis and discussion, this paper aims to provide valuable references for future research and clinical practice. We call for intensified research in these critical areas to promote the development and application of AI in the field of lacrimal disorder diagnosis and treatment.

【Abstract】 Objective To explore and practice the visual health management mode of Minhang District . Methods Introduce the visual health management mode of AI-assisted diagnosis in Minhang District; analyze and compare the traditional visual health management mode and AI-assisted visual health management mode, community visual health screening projects and completion conditions, screening files, eye disease discovery , referral, actual referral and return ; analyze and compare the visual health management mode, staff allocation, ophthalmic outpatient reception, and the satisfaction of visual health service. Results The difference in the discovery rate of major eye diseases between the traditional model and artificial intelligence-assisted diagnosis mode in both communities (?2=954.03, P＜0.01), the referral rate (?2=431.07，, P＜0.01). The awareness of AI-assisted diagnosis management improved in glaucoma in the two modes was statistically significant (?2=4.24, P＜0.05). Traditional model and artificial intelligence assisted diagnosis model of visual health service quality and service time is statistically significant (| Z | =2.75, | Z | =2.18, P＜0.05). Conclusion The visual health screening and management mode based on AI-assisted diagnosis is worthy of the promotion and application in other communities in the region.

Abstract Objective：Exploring holistic nursing strategies to improve the quality and efficiency of postanesthesia care unit (PACU) resuscitation in children patients undergoing ophthalmic laryngeal mask anesthesia.methods：Selecting a total of 24180 children patients who underwent general anesthesia and retained laryngeal mask airway for PACU resuscitation at Sun Yat sen Ophthalmic Center of Sun Yat sen University from January 2020 to December 2023, this study reviews and summarizes the nursing measures and resuscitation quality of children patients undergoing PACU resuscitation.Results：All patients underwent comprehensive care during the recovery period and successfully removed the laryngeal mask to complete anesthesia recovery. There were no cases of secondary intubation or unplanned transfer for treatment during the recovery period. After adopting personalized holistic nursing strategies, the average recovery time of PACU in children under laryngeal mask anesthesia was significantly shortened.The incidence of common postoperative complications（postoperative agitation 、hypoxemia and respiratory obstruction）and adverse nursing events（indwelling needle falls off、eye bandage fall off）have been decreasing year by year.These complications have been improved after treatment and care.Conclusion:Based on the characteristics of children patients undergoing general anesthesia in ophthalmology, adopting personalized holistic nursing strategies during the anesthesia recovery period is beneficial for successfully completing anesthesia recovery, reducing the incidence of anesthesia complications and adverse nursing events, improving the quality and efficiency of recovery, and meeting the needs of rapid recovery in ophthalmic day surgery.

Objective Explore 9 risk factor indicators and related eye symptoms closely related to the onset of RA dry eye syndrome, identify high-risk factors and prognostic factors that affect the occurrence of dry eye damage in patients with rheumatoid arthritis, and provide clinically effective detection i ndicators for the prevention and control of rheumatoid arthritis dry eye syndrome. Method A retrospective analysis was conducted on 150 rheumatoid arthritis (RA) patients (300 eyes) admitted to the Rheumatology Department of the First Affiliated Hospital of Yunnan University of Traditional Chinese Medicine from January 2023 to December 2024. Logistic regression analysis was used to divide the 150 selected rheumatoid arthritis patients into two groups: the rheumatoidarthritis dry eye group and the uncomplicated dry eye group. The experimental group and the control group were divided into two groups. Nine pre-set suspicious risk factors were tested and the data results were recorded. Conditional logistic regression analysis was used to screen for statistically significant in dependent risk factors and prognostic factors that caused dry eye Conclusion Anti SSA antibodies, duration of rheumatoid arthritis ESR and IL-6 are independent risk factors for dry eye syndrome in patients with rheumatoid arthritis. IL- 6 、 Positive initial screening of anti nuclear antibodies is an independent risk factor affecting the prognosis of patients with rheumatoid arthritis and dry eye syndrome.

Objective Explore 9 risk factor indicators and related eye symptoms closely related to the onset of RA dry eye syndrome, identify high-risk factors and prognostic factors that affect the occurrence of dry eye damage in patients with rheumatoid arthritis, and provide clinically effective detection indicators for the prevention and control of rheumatoid arthritis dry eye syndrome. Method A retrospective analysis was conducted on 150 rheumatoid arthritis (RA) patients (300 eyes) admitted to the Rheumatology Department of the First Affiliated Hospital of Yunnan University of Traditional Chinese Medicine from January 2023 to December 2024. Logistic regression analysis was used to divide the 150 selected rheumatoid arthritis patients into two groups: the rheum atoidarthritis dry eye group and the uncomplicated dry eye group. The experimental group and the control group were divided into two groups. Nine pre-set suspicious risk factors were tested and the data results were recorded. Conditional logistic regression analysis was used to screen for statistically significant in dependent risk factors and prognostic factors that caused dry eye.Conclusion Anti SSA antibodies, duration of rheumatoid arthritis ESR and IL-6 are independent risk factors for dry eye syndrome in patients with rheumatoid arthritis. IL- 6 、 Positive initial screening of anti nuclear antibodies is an independent risk factor affecting the prognosis of patients with rheumatoid arthritis and dry eye syndrome.

Immunoglobulin G4-related ophthalmic disease (IgG4-ROD) is a systemic condition characterized by the infiltration of IgG4-positive plasma cells and elevated serum IgG4 levels. The ocular manifestations of this disease can involve the lacrimal gland, orbital fat, infraorbital nerves, extraocular muscles, and eyelids, often accompanied by inflammatory and fibrotic processes. At the molecular level, IgG4-ROD is associated with the interaction of various immune cells and cytokines, including Th1, Th2, Treg, and Tfh cells, as well as the cytokines IL-4, IL-13, and TGF-β. These molecules collectively contribute to the pathogenesis of IgG4-ROD by promoting B cell activation and IgG4 production, as well as facilitating the development of fibrosis. Diagnosis is primarily based on histopathological features, while treatment typically involves glucocorticoids and immunosuppressive agents aimed at controlling immune-mediated inflammation and fibrosis, alleviating symptoms, and preventing organ damage. As our understanding of the molecular pathogenesis of IgG4-ROD deepens, treatment strategies are expected to be continuously refined to offer patients more precise and effective therapeutic options. This article summarizes and elucidates the key molecules and signaling pathways implicated in the pathogenesis of IgG4-related eye diseases, and reviews the interplay between autoimmunity and fibrosis, as well as their transformations, from a molecular perspective.

Abstract Objective: To establish a high-performance liquid chromatography (HPLC) method for the determination of content of Travoprost in Travoprost Eye Drops. Methods: The analytic column was Dikma C18 (50 mm×4.6 mm, 3μm) . Using phosphoric acid solution (take 1.0mL of phosphoric acid, dilute with water and make up to 1000mL, adjust the pH to 2.8 with 1mol/L sodium hydroxide solution)-acetonitrile (67:33) as mobile phase. The flow rate is 3.0 mL/min. The column temperature is 25℃; The detection wavelength is 220nm. The injection volume is 30μL. Results: The linear range of travoprost showed were well shown within 20.28~70.98μg?mL-1(r=0.998). The average recovery rate of travoprost was 100.3% with relative standard deviation (RSD) 2.0% (n=9). The method had high reproducibility. The reference solution and the test solution remain stable at room temperature for 48 hours.Conclusion: The method can be used for the determination of content of travoprost in Travoprost Eye Drops.