Abstract Purpose: To explore the status of current global research, trends and hotspots in the field of lupus retinopathy (LR). Methods: Publications related to LR from 2003 to 2022 were extracted from the Web of Science Core Collection (WOSCC). Citespace 6.2.R4 software was used to analyze the raw data. Bibliometric parameters such as publication quality, countries, authors, international cooperation, and keywords were taken into account. Results: A total of 315 publications were retrieved. The annual research output has increased significantly since 2010, especially since 2017. Marmor MF, Lee BR, and Melles RB contributed the highest number of articles published on LR. The top three publishing countries were the USA, China, and UK. Stanford University, Hanyang University, and Harvard Medical School were the top three producing institutions in the world for LR research. The top ten commonly used keywords include the following: systemic lupus erythematosus, retinopathy, retinal toxicity, antimalarial, hydroxychloroquine, optical coherence tomography, antiphospholipid syndrome, microvascular, optic neuritis, optical coherence tomography angiography. The keywords "optical coherence tomography angiography" and "vessel density" have exploded in recent years. Conclusion: By analyzing the current body of LR literature, specific global trends and hotspots for LR research were identified, presenting valuable information to track cutting-edge progress and for future cooperation between various authors and institutions.
Objectives: To evaluate the clinical value of peripheral retinal diseases in myopic patients examined by 200-degree ultra-wide field laser ophthalmoscope (Daytona). Methods: This was a prospective case-control study. We collected 1 000 myopic patients (2 000 eyes) who were scheduled to undergo refractive surgery in Aier Eye Hospital. They were examined by 200-degree ultra-wide field laser ophthalmoscope (Daytona) with non-mydriasis and three-mirror contact lens with mydriasis. The examination results were recorded and statistically analyzed. Results: A total of 230 cases (310 eyes) with peripheral retinopathy were found by 200-degree ultra-wide field laser ophthalmoscope (Daytona). The positive rate was 15.50%; 242 cases (322 eyes) with peripheral retinopathy were found by three- mirror contact lens, and the positive rate was 16.10%. The two methods were consistent in the detection of peripheral Retinopathy in myopic patients (the Kappa value is between 0.8 and 1.0). Conclusion: 200-degree ultra-wide field laser ophthalmoscope (Daytona) is an effective and rapid method for detecting peripheral retinopathy. It provides a broad clinical application prospects for peripheral retinopathy screening before refractive surgery.
Aims：To prepare sustained-released pirfenidone (PFD) loaded Poly (lactic-co-glycolic) acid (PLGA) microspheres, and to explore the effects of different fabricating factors on the microspheres in vitro. Methods：A single emulsification method and a homogenizer were used to prepare PFD-loaded PLGA microspheres. The processes of making the microspheres were changed to obtain different PFD-loaded PLGA microspheres. Ultra-performance liquid chromatography (UPLC) was used to measure the drug loading, drug encapsulation efficiency and in vitro release rate. The particle distribution was observed under a scanning electron microscope, and the lateral size of the microspheres was also measured by microscope. Results：A single emulsification method could successfully fabricate PFD-loaded PLGA microspheres with high drug encapsulation efficiency. Changing the factors of fabricating the microspheres could affect the particle size, drug loading, drug entrapment efficiency, and drug release rate in vitro. The PFD-loaded microspheres prepared under different situations could release nearly 50% of the drug on the first 0.5 day, and slowly release the drug in the following 13 days. Conclusions：A single emulsification method can efficiently prepare PFD-loaded PLGA microspheres, and achieve a good sustained release effect in vitro.
