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Overhanging glaucoma ff ltration bleb related to cataract surgery

Overhanging glaucoma ff ltration bleb related to cataract surgery

来源期刊: 眼科学报 | 2016年9月 第31卷 第3期 182-184 发布时间: 收稿时间:2024/12/1 13:41:49 阅读量:289
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关键词:
Overhanging ff ltration bleb trabeculectomy cataract surgery
Overhanging ff ltration bleb trabeculectomy cataract surgery
DOI:
doi: 10.3978/j.issn.1000-4432.2016.08.03
收稿时间:
2016-04-25 
修订日期:
 
接收日期:
2016-07-19 
A 74-year-old man presented with a three-year history of foreign body sensation in the right eye after cataract surgery. He underwent uneventful trabeculectomy with mitomycin C (MMC) in the right eye seven years ago. Slit-lamp examination revealed a large avascular filltration bleb overhanging on the cornea with a thin base connected to the conjunctiva. Preoperative ultrasound biomicroscopy (UBM) impressions were confirmed by leakage of aqueous from the incision intraoperatively. Surgical dissection and revision of the bleb was performed with satisfactory outcome. Histopathologic evaluation showed proliferation of fibrous tissue under the conjunctival epithelia with irregular cystoids change. The current case may be the first report of a post-trabeculectomy overhanging filtration bleb related to cataract surgery. The possible mechanism may be related to microleakage of the surgical wound after phacoemulsiff cation which initiated the healing and scarring process.
A 74-year-old man presented with a three-year history of foreign body sensation in the right eye after cataract surgery. He underwent uneventful trabeculectomy with mitomycin C (MMC) in the right eye seven years ago. Slit-lamp examination revealed a large avascular filltration bleb overhanging on the cornea with a thin base connected to the conjunctiva. Preoperative ultrasound biomicroscopy (UBM) impressions were confirmed by leakage of aqueous from the incision intraoperatively. Surgical dissection and revision of the bleb was performed with satisfactory outcome. Histopathologic evaluation showed proliferation of fibrous tissue under the conjunctival epithelia with irregular cystoids change. The current case may be the first report of a post-trabeculectomy overhanging filtration bleb related to cataract surgery. The possible mechanism may be related to microleakage of the surgical wound after phacoemulsiff cation which initiated the healing and scarring process.

Case presentation

A 74-year-old man presented with a three-year history of foreign body sensation in the right eye after cataract surgery. He underwent uneventful trabeculectomy with mitomycin C (MMC) in the right eye for advanced stage primary open angle glaucoma (POAG) seven years ago, and phacoemulsiff cation with intraocular lens implantation for senile cataract three years ago. From then on, he felt uncomfortable in the right eye with mild vision loss. On examination, his best-corrected visual acuity (BCVA) was 20/40. Intraocular pressure (IOP) was 18 mmHg without glaucoma medications. Slit-lamp examination revealed a large avascular filtration bleb overhanging on the cornea with a thin base connected to the conjunctiva (Figure 1A,B). No leakage from the filtration bleb could be detected (Figure 1C). Ultrasound biomicroscopy (UBM) confirmed that the bleb was connected to the conjunctiva through a thin base with partial free edge (Figure 2A), and the inner path of the ff ltration bleb was patent (Figure 2B).

Figure 1 Slit-lamp examination revealed a large avascular filtration bleb overhanging on the cornea

(A) with a thin base connected to the conjunctiva (B). No leakage could be seen (C). Black arrow: thin base connected to the conjunctiva.

Figure 2 Ultrasound biomicroscopy showed that the bleb was connected to the conjunctiva through a thin base with a partial free edge

(A). The inner passage of the ff ltration bleb was patent (B). White arrow: partial free edge. Yellow arrow: inner passage of the ff ltration bleb. 
The patient underwent surgical dissection of the overhanging bleb and scar tissues on the cornea. Leakage of aqueous could be seen from the base of the bleb. Revision of the bleb using superior conjunctival flap was performed. Histopathologic evaluation showed proliferation of fibrous tissue under the conjunctival epithelia with irregular cystoids change (Figure 3A,B).

Figure 3 Histopathologic evaluation showed proliferation of ff brous tissue under the conjunctival epithelia (A) with irregular cystoids (B).


On the first post-operative day, BCVA was 20/40 and IOP was 15 mmHg. The bleb was flat and diffuse (Figure 4A). Six months later, BCVA increased to 20/25, while the IOP was stable and the bleb was functioning well (Figure 4B,C). 

Figure 4 Post-operative slit-lamp examination.


(A). The bleb was wellmaintained six months after surgery (B) without leakage (C). 

Discussion

Large overhanging blebs are an uncommon complication of glaucoma filtration surgery. Though the pathogenesis is unknown, it may be related to the use of MMC. Its shape varies, especially after application of MMC (1). In the current case, the occurrence of such bleb appeared to be related to cataract surgery instead, evidenced by the following two signs. First, foreign body sensation and uncomfortable feeling appeared after the cataract surgery. Second, for the two-side phacoemulsification on the right eye, the side incision was on the superior peripheral cornea near the ff ltration bleb, which might be interrelated.

It has been reported that the size of functioning filtration bleb decreased and IOP increased after phacoemulsiff cation (2). There has also been a report of an inadvertent bleb developing after phacoemulsification (3). However, the current case may be the ff rst report of a post-trabeculectomy overhanging filtration bleb related to cataract surgery. The possible mechanism may be related to microleakage of the surgical wound of the side incision after phacoemulsiff cation which initiated the healing and scarring process (3). Thus, the morphology of the bleb is similar to a conjunctival granuloma with a thin base connected to the bleb.

Excision and revision of overhanging blebs are indicated when they are symptomatic or leaking. However, complications such as bleb leakage or failure occurred occasionally (4). Use of indocyanine green during excision or bleb revision guided by anterior segment optical coherence tomography has been reported with good results (5). Anis et al. reported sutureless revision with the aid of corneal contact lenses in six cases of overhanging filtering blebs (4). Success was achieved in five, while one patient had bleb leak requiring suture repair (4). In the current case, preoperative UBM impressions were confirmed by leakage of aqueous from the incision intraoperatively. Therefore, suture revision with superior conjunctival flap was performed with satisfactory outcome.
1、Kapoor KG, Syed MF. Dramatic dysesthetic overhanging bleb. Int Ophthalmol 2011;31:403-4.
2、Rebolleda%20G%2C%20Mu%C3%B1oz-Negrete%20FJ.%20Phacoemulsiff%20cation%20in%20eyes%20with%20functioning%20ff%20ltering%20blebs%3A%20a%20prospective%20study.%20%20Ophthalmology%202002%3B109%3A2248-55.
3、Zetterstr%C3%B6m%20C.%20Filtration%20bleb%20after%20phacoemulsiff%20cation.%20Acta%20Ophthalmol%20Scand%202003%3B81%3A188-90.
4、Anis S, Ritch R, Shihadeh W, et al. Sutureless revision of overhanging ff ltering blebs. Arch Ophthalmol 2006;124:1317-20.
5、Kojima S, Inoue T, Kawaji T, et al. Filtration bleb revision guided by 3-dimensional anterior segment optical coherence tomography. J Glaucoma 2014;23:312-5.
1、This work is supported by the Natural Science Foundation of Guangdong Province in China (grant No. 2015A030313052)()
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