患者，男，54 岁，因“双眼异物感伴眼痒 2 周”在北京怀柔医院眼科就诊。自诉 1 d 前自行从眼内取出白色虫体 1 条。裂隙灯检查发现左眼结膜囊内可见白色虫体 2 条，用眼科镊子将其取出，并送病理科检查。就诊结束后嘱患者左氧氟沙星眼液滴左眼，4次/d 。后病理科证实虫体为结膜吮吸线虫。5 d 后患者复诊，诉左眼仍眼痒伴异物感，再次行裂隙灯检查检深部穹隆白色虫体 1 条，取出虫体，并使用生理盐水加压冲洗结膜囊，嘱患者局部抗生素点眼，门诊随访 3 周未见复发。

A 54-year-old patient was admitted to the Department of Ophthalmology in Beijing Huairou Hospital due to the itch of eyes for 2 weeks. He said that a white worm was removed from the eye the day before the visit. Two white worms were found in the conjunctival sac from the left eye and we removed them with the tweezers and then sent to pathology department for further examination. The patient was told to use the levofloxacin eye drop 4 times a day. After 2 days, it was confirmed that the worms were Thelazia callipaeda; after 5 days, the patient came back for further consultation and complained that the itching and foreign body sensation didn’t disappear. And then a white worm was found in the deep conjunctival sac from the left eye. The worm was removed, and the conjunctival sac was flushed with saline. The patient was told to continue using the levofloxacin eye drop. During 3-week followup, no recurrence was found.

目的：探讨基质金属蛋白酶-3(matrix metalloproteinases-3，MMP-3)基因多态位点与承德地区人群2型糖尿病视网膜病变的遗传易感性的关系。方法：应用病例对照研究方法，选取195例糖尿病视网膜病变患者(DR组)，其中非增殖性糖尿病视网膜病变(non-proliferative diabetic retinopathy，NPDR)组(n=152)和增殖性糖尿病视网膜病变(proliferative diabetic retinopathy，PDR)组(n=43)，205例单纯糖尿病患者(DM组)和261例正常对照组(Control组)，采用限制性片段长度多态性(restrictive fragment length polymorphism，RFLP)-聚合酶链反应(polymerase chain reaction，PCR)方法检测MMP-3的基因多态性。结果：MMP-3-1171 5A/6A的等位基因及基因型频率分布在Control组，DM组和DR组之间差异无显著性(P=0.474和P=0.407)。MMP-3-1171 5A/6A的等位基因及基因型频率分布在NPDR和PDR组之间差异无显著性(P=0.724和P=0.820)。结论：MMP-3-1171 5A/6A基因多态性与2型糖尿病视网膜病变的遗传易感性无关。

目的：探讨基质金属蛋白酶-3(matrix metalloproteinases-3，MMP-3)基因多态位点与承德地区人群2型糖尿病视网膜病变的遗传易感性的关系。方法：应用病例对照研究方法，选取195例糖尿病视网膜病变患者(DR组)，其中非增殖性糖尿病视网膜病变(non-proliferative diabetic retinopathy，NPDR)组(n=152)和增殖性糖尿病视网膜病变(proliferative diabetic retinopathy，PDR)组(n=43)，205例单纯糖尿病患者(DM组)和261例正常对照组(Control组)，采用限制性片段长度多态性(restrictive fragment length polymorphism，RFLP)-聚合酶链反应(polymerase chain reaction，PCR)方法检测MMP-3的基因多态性。结果：MMP-3-1171 5A/6A的等位基因及基因型频率分布在Control组，DM组和DR组之间差异无显著性(P=0.474和P=0.407)。MMP-3-1171 5A/6A的等位基因及基因型频率分布在NPDR和PDR组之间差异无显著性(P=0.724和P=0.820)。结论：MMP-3-1171 5A/6A基因多态性与2型糖尿病视网膜病变的遗传易感性无关。