目的:探讨垂体腺瘤对眼视功能损害的临床表现。

方法:对 126 例( 252 只眼)垂体腺瘤患者进行视力、视野、荧光眼底血管造影(Fundus fuorescein angiography, FFA)、图形视诱发电位(Pattem visual evoked potential, PVEP)及眼底检査。

结果:视力下降 186 只眼,占73.8%。眼底原发性视神经萎缩 130 只眼,占51.6%。视野缺损 156 只眼,占69.6%。PVEP异常 160 只眼,占88.9%。26.2%的患者以眼部异常为首诊症状,其中16.7%曾被诊断为眼科疾病。

结论:垂体腺瘤可引起视功能的损害,充分认识垂体腺瘤在眼部的临床特点,有助于早期诊断及时治疗。

Purpose : To investigate the clinical manifestation of damage of visual function causedby pituitary adenoma.

Methods: Visual acuity, visual field, fundus fluorescein angiography (FFA), pattemvisual evoked potential (PVEP) and examination fundus were performed in 126 cases(252 eyes)of pituitary tumor.

Results :There was 73.8% (186 eyes) of patients with decreased visual acuity, 51.6%(130 eyes) with primary optic atrophy, 69.6 %(156 eyes) with the defects of visualfield and 88.9%(160 eyes) with abnormal PVEP. Abnormal ophalmological manifestationwas the first diagnostic symptom in 26.2%, and 16.7% was misdiagnosed as eye diseases.

Conclusions: Pituitary tumor could cause defection of visual function. lt is helpful toearly diagnosis and timely treatment by fully understanding clinical features in the eyewith pituitary tumor.

报道1例睫状体无色素上皮腺瘤(adenoma of nonpigmented ciliary epithelium，ANPCE)并进行相关文献复习。患者主要症状为左眼视力逐渐下降3个月，视物不清半个月。经眼部检查及左眼超声生物显微镜(ultrasound biomicroscopy，UBM)检查显示左眼虹膜周边隆起，边界清晰。予虹膜睫状体肿物切除术并行常规病理检查：光镜下肿瘤组织由分化好的上皮细胞组成，排列成腺泡状及条索状，细胞间可见红染无结构的基底膜样物；免疫组织化学表达：S-100(+)、Vimentin(+)、EMA(+)、CKpan(+)、Melan-A(+)；最终病理诊断ANPCE。手术后截至随访日期，术后3个月无疾病进展。

A case of adenoma of nonpigmented ciliary epithelium (ANPCE) was reported and relevant literatures were reviewed. The left eye visual acuity of the patient gradually decreased for 3 months, and half a month was blurred vision. The vision examination and ultrasound biomicroscopy (UBM) from the left eye examination revealed a bulge in the peripheral iris in the left eye, with the boundaries are clear. The left eye was treated with ciliary mass resections and routine pathological examination: microscopy showed that the tumor tissue consists of well-differentiated epithelial cells, the tumor cells were arranged in tubes and cords, between the cells were seen red-stained unstructured basement membrane; immunohistochemistry showed: S-100 (+), Vimentin (+), EMA (+), CKpan (+), Melan-A (+); the final pathological diagnosis was ANPCE. There was no progression of the disease during the 3 months following the surgery on the follow-up date.