Objective To analyze the clinical application of optical coherence tomography (OCT) and color fundus examination in fundus examination before cataract surgery. Methods A total of 160 patients (237 eyes) undergoing elective cataract surgery who were admitted to our hospital from From January 2021 to February 2022 were selected for inclusion in the study. All patients underwent OCT examination and fundus color photography before surgery. Comparative analysis of the detection rate of the two methods of diagnosis of ocular fundus disease. Results Preoperative OCT detected 51 eyes with fundus disease, preoperative fundus color photography detected 22 eyes with fundus disease, and preoperative OCT combined with fundus color photography detected 58 eyes with fundus disease.The detection rate of preoperative OCT for fundus diseases was significantly higher than that of fundus color photography (21.52% vs 9.28%, χ2= 13.618%, P﹤0.001); the detection rate of preoperative OCT combined with fundus color photography for diagnosis of fundus diseases was slightly higher In OCT, there was no significant difference between the two (24.47% vs 21.52%, χ2= 0.584, P=0.445); the detection rate of OCT combined with fundus color photography before surgery was significantly higher than that of fundus color photography (24.47% vs 9.28%), χ2=19.489, P<0.001). Conclusions OCT examination has a high accuracy in diagnosing macular lesions, and its combined examination with ocular ultrasound can improve the clinical diagnosis of fundus disease before cataract surgery.
Zonulopathy (including zonular laxity and dehiscence) can cause anterior displacement of iris-lens diaphragm, shallow anterior chamber, anterior chamber angle closure and elevated intraocular pressure, resulting in angle closure glaucoma (ACG). Idiopathic zonulopathy is common in primary angle closure glaucoma (PACG), which may be one of the pathogenic mechanisms of PACG. But further prospective cohort studies are needed to verify that. ?e proportion of diagnosis ofzonulopathy in PACG patients before cataract extraction in combination with anti-glaucoma surgery is low by signs of anterior chamber depth differences between both eyes, iridodonesis / phacodonesis and UBM examination. Hence, most cases with zonulopathy in PACG are found during the operation, which is called occult zonulopathy. At present, the diagnosis of zonulopathy in PACG is often made according to the intraoperative manifestations, such as visible capsular equator aěer mydriasis, wrinkling of the anterior capsule during manual capsulorhexis, infolding of peripheral capsule or visualization of the capsular equator during the cortical or nuclear removal; loose or ěoppy capsular bag. According to different ranges and severities ofzonulopathy, phacoemulsi?cation combined with intraocular lens (IOL) implantation, with or without capsule tension ring implantation, or sclera-fixated IOL is selected. PACG patients should be paid more attention to the diagnosis and differentiation ofzonulopathy before and during operation, fully improved the preoperative examination, and formulated individualized treatment plans to ensure the safety and efficacy of operation.
Integrating the ideological and political concept of the curriculum into professional courses to cultivate morality and talents is a common practice in universities. This paper briefly introduces the commonly used ophthalmic rodent models as useful tools in six specific aspects: corneal disease, cataract, glaucoma, retinal disease, choroidal disease, and uveitis, in the field of animal technology, according to the features of laboratory skills training courses, as well as students' demand for pre-class preparation and after-class review. By summarizing the modeling steps, eye phenotypes, as well as some principles, advantages, and disadvantages, this paper provides a valuable reference for the selection and establishment of animal models of ophthalmic diseases. Additionally, the teaching design optimizing preview and review provides useful exploration and practice of ideological and political teaching in molecular medicine-related courses.
Diabetic retinopathy (DR) is one of the microvascular complications of diabetic mellitus (DM), which occurs when the blood-retinal barrier (BRB) is lost due to the lesion. Diabetic macular edema (DME) can lead to irreversible vision loss, and the clinical tools used to diagnose DME include fundus photography, OCT, and FFA. In addition to laser photocoagulation, anti-VEGF therapy and anti-inflammatory therapy, some emerging therapies and combination therapy have become the main trend in the treatment of DME.
Objective : To observe the changes of ophthalmic artery and central retinal artery blood flow in contralateral healthy eyes of patients with central retinal artery occlusion (CRAO) and their correlation with time from onset to visit. Methods: 32 patients (32 eyes) who were confirmed as retinal artery occlusion by clinical examination were randomly selected as the affected eye group, 32 contralateral healthy eyes were taken as the healthy eye group and 34 healthy people (34 eyes) as the control group. All eyes were examined by best corrected visual acuity (BCVA), slit lamp microscope, indirect ophthalmoscope, intraocular pressure and color Doppler flow imaging (CDFI). CRAO patients underwent FFA examination within 3 days. When BCVA statistics are performed, it was converted to the logarithm of minimal angle resolution (LogMAR). Results: CRAmax in the affected eye group and healthy eye group was significantly lower than that in the?control group, while CRAmin in the healthy eye group was significantly higher than that in the?control group, and the differences were statistically significant (t=4088, 2.888, 2.701, p=0.001,?0.001, 0.09; p < 0.05); compared with the control group, there were no significant differences in?OAmax, OAmin, OAPI, CRAPI (affected eye group and healthy eye group) and CRAmin (affected?eye group) (t=1. 652, 0.863, 0.202, 0.769, 1.106, 0.105, 0.908, 0.122, 0.486, p=0. 104, 0.397,?0.841, 0.445, 0.273, 0.881, 0.367, 0.903, 0.629; p > 0.05). Spearson?correlation analysis showed that there were significant positive correlations between CRAmax of?healthy eyes group and the time frm upset to visit(r =-0. 471, p=0.006; p < 0.05). Conclusion: The ocular blood flow of contralateral healthy eyes in CRAO patients is affected by CRAO, and subclinical symptoms may exist before the onset of CRAO.
As a common ocular surface disease in ophthalmology clinics, dry eye has been perplexing the medical community because of its complex pathogenesis. Therefore, early detection and early treatment are particularly important. In the course of clinical treatment, the author found that if the dry eye is untreated and becomes refractory dry eye, it will appear ciliary weakness and difficult to open eyes; Major's syndrome (MG), no similar report has been found after consulting the literature. Now we will introduce these two rare diseases, hoping to attract the attention of clinicians, so as to avoid more serious complications.
