泪器病专栏

泪道支架材料的研究进展

Research progress on lacrimal duct stent materials

:363-370
 
泪道阻塞是临床常见的眼科疾病,主要表现为溢泪、反复感染等症状,严重影响患者的生活质量。传统治疗方法主要采用硅胶或金属支架置入术,这些材料虽然能够暂时维持泪道通畅,但由于其不可降解性、容易移位、易形成生物膜导致感染等固有缺陷,往往需要二次手术取出,给患者带来额外的痛苦和经济负担。随着材料科学和生物医学工程的发展,新型支架材料的研发为解决这些问题提供了新的思路。文章聚焦新型材料如可降解材料、3D打印个性化支架、复合材料及表面改性技术等,这些材料可通过材料降解、精准适配或多功能整合提升临床疗效,但在降解速率调控、3D打印精度及成本方面仍面临诸多挑战。此外,这些新技术的长期安全性和有效性还需要更多临床数据的支持,在未来仍需不断探索,开发更精准的降解速率调控方法,优化3D打印流程以提高精度,降低材料制备的成本,探索更高效的复合材料制备技术。同时,要加强基础研究,推动更多创新技术在临床的应用,开发出更安全、更有效的新型泪道支架材料,为泪道阻塞患者提供更优质的治疗方案,推动泪道疾病治疗向精准微创化方向发展。
Lacrimal duct obstruction is a common clinical ophthalmic condition characterized by symptoms such as epiphora and recurrent infections, significantly impairing patients' quality of life. Traditional treatments primarily involve the implantation of silicone or metal stents. While these materials can temporarily maintain lacrimal duct patency, their inherent drawbacks—such as non-degradability, susceptibility to displacement, and tendency to form biofilms leading to infections—often necessitate secondary surgeries for removal, imposing additional physical and financial burdens on patients.Advances in materials science and biomedical engineering have introduced novel stent materials as potential solutions to these challenges. This article focuses on emerging materials such as biodegradable polymers, 3D-printed personalized stents, composite materials, and surface modification technologies. These innovations can enhance clinical outcomes through material degradation, precise customization, or multifunctional integration. However, challenges remain in regulating degradation rates, improving 3D printing precision, and reducing costs.Furthermore, the longterm safety and efficacy of these technologies require more clinical data for validation. Future research should explore more precise degradation rate control methods, optimize 3D printing processes to enhance accuracy, lower material production costs, and develop more efficient composite material fabrication techniques. Concurrently, strengthening fundamental research and promoting the clinical application of innovative technologies will be crucial to developing safer and more effective lacrimal duct stent materials. Such advancements will provide superior treatment options for patients with lacrimal duct obstruction and drive the field toward minimally invasive and precision medicine approaches.
眼科药学专题

大麻二酚在眼部疾病中的应用前景

The application prospect of cannabidiol in eye diseases

:497-503
 
大麻二酚(Cannabidiol,CBD)为大麻提取物中的一种非成瘾性活性成分,是目前研究最热门的植物源性大麻素之一。内源性大麻素系统(endocannabinoid system,ECS)在眼表和视网膜中的研究也已经取得显著进展。CBD可以广泛存在于整个眼球,且其分布和功能具有组织特异性。近年来研究发现CBD具有良好的抗炎、抗损伤、降低眼压及神经保护作用。该文详细介绍了CBD在眼部疾病中的研究进展,以及其对各种眼部疾病的治疗潜力。此外,还讨论了CBD在临床眼科治疗中的应用面临的挑战和未来的发展方向。
Cannabidiol(CBD), a non-addictive active ingredient in cannabis extract, is one of the most popular plant-derived cannabinoids. The study on the endoenuous cannabionoid system (ESC) has made significant progress in the ocular surface and retina. CBD exists extensively in the eyeball, and its distrution and functions of anti-inflammatory,antiinjury, reducing intraocular pressure, and neuroprotective effects have been found. This article introduces the research progress in CBD in eye diseases and the therapeutic potential of cannabidiol for various eye diseases in detailed.Furthermore, the challenges and prospect for the application of CBD in clinical ophthalmology were discussed.
其他期刊
  • 眼科学报

    主管:中华人民共和国教育部
    主办:中山大学
    承办:中山大学中山眼科中心
    主编:林浩添
    主管:中华人民共和国教育部
    主办:中山大学
    浏览
  • Eye Science

    主管:中华人民共和国教育部
    主办:中山大学
    承办:中山大学中山眼科中心
    主编:林浩添
    主管:中华人民共和国教育部
    主办:中山大学
    浏览
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