目的：观察羊膜移植手术对于减少碱烧伤后角膜新生血管的疗效。

方法：回顾性病例对照研究。2006－2010 年期间该院收治的 Ⅲ 度角膜碱烧伤的患者 19 例 23 眼，其中行羊膜移植术（治疗组）11 例 13 眼，未行羊膜移植术（对照组）8 例 10 眼。该两组的年龄和手术外的处理基本匹配。伤后 3 d 治疗组行羊膜移植术。分别在伤后 14、60 d 测量各组角膜新生血管面积。应用 SPSS 12.0 统计学软件将此两组的面积进行配对 t 检验，以 P < 0.05 作为差异有统计学意义。

结果：在烧伤后 14 d 治疗组新生血管面积（62.133 ± 8.571）mm²，明显低于对照组（89.561 ± 9.741）mm²，治疗组较对照组减低 30.6%，两组差异具有统计学意义（P < 0.05）。烧伤后 60 d 治疗组新生血管面积（112.019 ± 17.362）mm²，明显低于对照组（129.481 ± 13.534）mm²，治疗组较对照组减低 13.5%，两组差异具有统计学意义（P < 0.05）。

结论：羊膜移植术能明显抑制碱烧伤所致角膜新生血管的生长。

Purpose: To study the curative effect of amnion membrane transplantation on decreasing corneal neovascularization (CNV) induced by alkali burn.

Methods: It was a non-randomized retrospective case-control study. Among 19 cases (23 eyes) of third-degree alkali burns from 2006 to 2010, 11 cases (13 eyes) were performed with amnion membrane transplantation operation, and others were not. Amnion membrane transplantation was performed at the 3^rd day after burn in the treatment group. Ages and treatments beyond surgery of double groups were matched. Areas of CNV in double groups were measured at the 14^th day and 60^th day after burn.

Results: Area of CNV in the treatment group was (62.133 ± 8.571) mm² at the 14^th day after burn, and was 30.6% lower than that in the control group. Area of CNV in the treatment group was (112.019 ± 17.362) mm² at the 60^th day after burn, and was 13.5% lower than that in the control group. There was statistical significance (P < 0.05).

Conclusion: Amnion membrane transplantation operation can inhibit the growth of corneal neovascularization induced by alkali burn.