Purpose: To investigate gender differences in lens thickness (LT) and central anterior chamber depth (ACD) in normal subjects, and to assess age-associated changes in these measures.

Methods: The anterior chamber depth (ACD) and lens thickness (LT) of 150 normal subjects (150 eyes) were measured by anterior segment optical coherence tomography (AS-OCT). Gender differences were assessed by independent t-test, and correlation analysis was used to examine the effect of age.

Results: The mean values of ACD and LT were 2.69 ± 0.32 mm and 4.85 ± 0.43 mm, respectively. Women had a significantly lower mean ACD as compared to men (2.56 ± 0.33 mm vs. 2.85 ± 0.29 mm; P < 0.05). No statistically significant difference was found in LT between male and female subjects (P > 0.05). Correlation analysis findings suggest that LT increases with age (r = 0.83,P < 0.05)，and that ACD decreases with age (r=-0.57,P < 0.05). After controlling for LT, no significant correlation was observed between age and ACD (P > 0.05).

Conclusion: The ACD of female subjects was, on average, shallower than that of their male counterparts. Aging was associated with increasing LT, and the observed narrowing of ACD with age might be partially mediated by the increasing LT. (Eye Science 2012; 27:124-126)

Keywords: anterior chamber; lens; age; primary angle-closure glaucoma

Purpose: To investigate gender differences in lens thickness (LT) and central anterior chamber depth (ACD) in normal subjects, and to assess age-associated changes in these measures.

Methods: The anterior chamber depth (ACD) and lens thickness (LT) of 150 normal subjects (150 eyes) were measured by anterior segment optical coherence tomography (AS-OCT). Gender differences were assessed by independent t-test, and correlation analysis was used to examine the effect of age.

Results: The mean values of ACD and LT were 2.69 ± 0.32 mm and 4.85 ± 0.43 mm, respectively. Women had a significantly lower mean ACD as compared to men (2.56 ± 0.33 mm vs. 2.85 ± 0.29 mm; P < 0.05). No statistically significant difference was found in LT between male and female subjects (P > 0.05). Correlation analysis findings suggest that LT increases with age (r = 0.83,P < 0.05)，and that ACD decreases with age (r=-0.57,P < 0.05). After controlling for LT, no significant correlation was observed between age and ACD (P > 0.05).

Conclusion: The ACD of female subjects was, on average, shallower than that of their male counterparts. Aging was associated with increasing LT, and the observed narrowing of ACD with age might be partially mediated by the increasing LT. (Eye Science 2012; 27:124-126)

Keywords: anterior chamber; lens; age; primary angle-closure glaucoma

Abstract

Purpose: Nanophthalmos is a rare congenital disorder associated with a high incidence of angle-closure glaucoma. We followed the clinical manifestations of three siblings to evaluate their responses to various treatments.
Methods:  Three sisters with nanophthalmos were followed from 2000 to 2013. Glaucoma and cataract treatments were performed whenever indicated.
Results: The oldest sister had chronic elevation of intraocular pressure(IOP) and underwent laser peripheral iridotomy (LPI) on both eyes, followed by uneventful phacoemulsification with intraocular lens (IOL) implantation on the left eye and phacotrabeculectomy with IOL implantation on the right eye. The middle sister had acute elevation of IOP and initially underwent phacoemulsification combined with implantation of two IOLs on her left eye and LPI on her right eye. Severe uveal effusion occurred when phacoemulsification was performed on her right eye 6 years later, but ultimately was com pletely resolved. In both sisters, stable IOP and visual results were achieved after lensectomy. The youngest sister, who had suspected angleclosure, achieved a stable IOP and visual results with prophylactic LPI alone.
Conclusion: In nanophthalmic eyes, the severity of the disease may foreshadow the severity of surgical complications and responses to therapy. (Eye science 2013 ; 28:113-118)

Abstract
Purpose: Nanophthalmos is a rare congenital disorder associated with a high incidence of angle-closure glaucoma. We followed the clinical manifestations of three siblings to evaluate their responses to various treatments.
Methods: Three sisters with nanophthalmos  were followed from 2000 to 2013. Glaucoma and cataract  treatments  were performed whenever indicated.
Results: The oldest sister had chronic elevation of intraocular pressure(IOP) and underwent laser peripheral iridotomy (LPI) on both eyes, followed by uneventful phacoemulsification with intraocular lens (IOL) implantation on the left eye and phacotrabeculectomy with IOL implantation on the right eye. The middle sister had acute elevation of IOP and initially underwent phacoemulsification combined with implantation of two IOLs on her left eye and LPI on her right eye. Severe uveal effusion occurred when phacoemulsification was performed on her right eye 6 years later , but ultimately was com pletely resolved. In both sisters, stable IOP and visual results were achieved after lensectomy. The youngest sister, who had suspected angle-closure, achieved a stable IOP and visual results with prophylactic LPI alone.
Conclusion: In nanophthalmic eyes, the severity of the disease may foreshadow the severity of surgical complications and responses to therapy. (Eye science 2013 ; 28:113-118)

A 74-year-old man presented with a three-year history of foreign body sensation in the right eye after cataract surgery. He underwent uneventful trabeculectomy with mitomycin C (MMC) in the right eye seven years ago. Slit-lamp examination revealed a large avascular filltration bleb overhanging on the cornea with a thin base connected to the conjunctiva. Preoperative ultrasound biomicroscopy (UBM) impressions were confirmed by leakage of aqueous from the incision intraoperatively. Surgical dissection and revision of the bleb was performed with satisfactory outcome. Histopathologic evaluation showed proliferation of fibrous tissue under the conjunctival epithelia with irregular cystoids change. The current case may be the first report of a post-trabeculectomy overhanging filtration bleb related to cataract surgery. The possible mechanism may be related to microleakage of the surgical wound after phacoemulsiff cation which initiated the healing and scarring process.

A 74-year-old man presented with a three-year history of foreign body sensation in the right eye after cataract surgery. He underwent uneventful trabeculectomy with mitomycin C (MMC) in the right eye seven years ago. Slit-lamp examination revealed a large avascular filltration bleb overhanging on the cornea with a thin base connected to the conjunctiva. Preoperative ultrasound biomicroscopy (UBM) impressions were confirmed by leakage of aqueous from the incision intraoperatively. Surgical dissection and revision of the bleb was performed with satisfactory outcome. Histopathologic evaluation showed proliferation of fibrous tissue under the conjunctival epithelia with irregular cystoids change. The current case may be the first report of a post-trabeculectomy overhanging filtration bleb related to cataract surgery. The possible mechanism may be related to microleakage of the surgical wound after phacoemulsiff cation which initiated the healing and scarring process.