目的：探讨临床分离的铜绿假单胞菌感染所致眼内炎的临床特点及对常用抗菌药物耐药情况，为临床合理使用抗菌药物提供治疗依据。方法：回顾2013年1月—2024年12月在中山大学中山眼科中心确诊感染铜绿假单胞菌的眼内炎患者资料，记录并分析患者临床特点及对常用抗菌药物耐药情况。结果：44例确诊感染铜绿假单胞菌的眼内炎患者，2例患者采取保守治疗，42例患者接受外科手术治疗。其中13例患者行玻璃体腔内注射抗菌药物及玻璃体切割术，10例患者行玻璃体切割术，19例患者行眼球摘除术。治疗后，1例患者视力达到20/400，3例患者视力为指数视力（finger count, FC），9例患者视力为手动视力（hand move, HM），5例患者视力为光感（light perception, LP），26例患者视力无光感（no light perception, NLP）。体外药敏试验显示，铜绿假单胞菌对阿米卡星、美罗培南、妥布霉素敏感度为100.0%；对庆大霉素敏感度为97.5%；对左氧氟沙星、环丙沙星敏感度为95.0%；对头孢吡肟、亚胺培南敏感度为80.0%；对头孢他啶、氧氟沙星敏感度为75.0%；对氯霉素、头孢唑啉、头孢呋辛、头孢曲松及复方磺胺甲噁唑的敏感度均为0%。结论：铜绿假单胞菌性眼内炎患者的视力预后较差，眼球摘除率居高不下。铜绿假单胞菌对阿米卡星、美罗培南、妥布霉素表现出较好的敏感性。

Objective: To explore the clinical characteristics and antibiotic resistance patterns of endophthalmitis induced by Pseudomonas aeruginosa at our hospital from January 2013 to December 2024, with the aim of providing evidence to support the rational clinical use of antimicrobial agents. Methods: A retrospective analysis was conducted on patients diagnosed with Pseudomonas aeruginosa endophthalmitis at Zhongshan Ophthalmic Center, Sun Yat-sen University, during the period from January 2013 to December 2024. Clinical features and antibiotic resistance profiles of the patients were documented and analyzed. Results: Among the 44 patients, 2 received conservative treatment. The remaining 42 patients underwent surgical intervention: 13 patients received intravitreal antibiotic injection combined with vitrectomy, 10 patients underwent vitrectomy alone, and 19 patients required enucleation. Post-treatment visual outcomes were as follows: 1 patient achieving 20/400 vision, 3 patients had with finger count (FC) vision, 9 with hand move (HM), 5 patients with light perception (LP), and 26 patients with no light perception (NLP). In vitro drug susceptibility tests revealed that Pseudomonas aeruginosa was 100.0% sensitive to amikacin, meropenem and tobramycin; 97.5% sensitive to gentamicin; 95.0% sensitive to levofloxacin and ciprofloxacin; 80.0% sensitive to cefepime and imipenem; 75.0% sensitive to ceftazidime and ofloxacin; and 0% sensitive to chloramphenicol, cefazolin, cefuroxime, ceftriaxone and cotrimoxazole. Conclusions: The visual prognosis of patients with Pseudomonas aeruginosa endophthalmitis remains poor, with a high rate of enucleation. The pathogen demonstrated favorable susceptibility to amikacin, meropenem, and tobramycin.