泪器病专栏

曲安奈德在治疗慢性泪囊炎鼻内镜术后造瘘口肉芽增生中的应用

Application of intralesional triamcinolone acetonide injections in the treatment of ostium granulomas following endoscopic dacryocystorhinostomy

:446-453
 

目的:分析慢性泪囊炎患者鼻内镜下泪囊鼻腔造瘘口术后的远期肉芽增生情况,评价物理清除联合曲安奈德(triamcinolone acetonide,TA)局部注射治疗慢性泪囊炎鼻内镜术后造瘘口肉芽组织增生的效果。方法:回顾性分析接受鼻内镜手术的慢性泪囊炎患者98例115眼。随访收集术后造瘘口肉芽组织增生发生情况,分析肉芽增生与无肉芽增生患者的临床特征。对有肉芽增生的患者26例31眼,根据治疗方式分为物理清除联合TA局部注射组13例16眼和单纯物理清除组13例15眼,比较2组间治疗有效率。结果:鼻内镜术后造瘘口肉芽增生病例共31眼(26.96%)。物理清除联合TA组的治愈率、好转率分别为93.75%、6.25%,物理清除组相应为60%、33.33%。组间比较差异有统计学意义(< 0.05)。结论:物理清除联合TA局部注射治疗泪囊炎鼻内镜术后造瘘口肉芽组织增生安全、有效。

Objective: This study aimed to analyze the formation of ostium granulomas following endonasal endoscopic dacryocytostomy (DCR) in patients with chronic dacryocystitis and to evaluate the efficacy of excision combined with triamcinolone (TA) injection for treating ostium granulosis after endoscopic dacryocystorhinostomy. Methods: A restrospective analysis was conducted on 98 patients (115 eyes) with chronic dacryocystitis who underwent endoscopic dacryocystorhinostomy.  Postoperative growth of the ostium granulomas was monitored, and clinical characteristics were compared between patients with and without ostium granulomas. Among these, 26 cases (31 eyes) of ostium granuloma were identified and randomly assigned to either an excision combined with triamcinolone injection group (13 cases with 16 eyes) or excision-only group (13 cases with 15eyes) based on the treatment method. The effective ratebetween two groups was compared. Results: Ostium granulomas occurred in 31 eyes (26.96%). The cure rate and improvement rate in the excision combined with TA group were 93.75% and 6.25%, respectively, whereas in the excision-only group, they were 60% and 33.33%. These differences were statistically significant (< 0.05).  Conclusions: Excision combined with intralesional triamcinolone acetonide injections proved effective in promoting the regression of ostium granuloma after DCR.

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  • 眼科学报

    主管:中华人民共和国教育部
    主办:中山大学
    承办:中山大学中山眼科中心
    主编:林浩添
    主管:中华人民共和国教育部
    主办:中山大学
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  • Eye Science

    主管:中华人民共和国教育部
    主办:中山大学
    承办:中山大学中山眼科中心
    主编:林浩添
    主管:中华人民共和国教育部
    主办:中山大学
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