Objective: To investigate the advances and trends of heat shock proteins in ophthalmology published from 2003 to 2013. Methods: The Web of Science database was used to retrieve the literature on heat shock proteins in ophthalmology published from January 1, 2003 to December 26, 2023. Bibliometric methods and VOSviewer and CiteSpaces software were used to analyze and visualize data, including publication count, countries, organizations, journals, authors, keywords and subject categories. Results: A total of 1079 publications related to heat shock proteins in ophthalmology were included, and the overall number of publications was fluctuating. The United States (n=394) was the leading contributor among countries. Investigative Ophthalmology & Visual Science (n=80) was the journal with the largest number of publications. Glaucoma and retinal ganglion cells, gene and protein expression, crystallin and cataract was identified as the research hotspots. Glaucoma, cholesterol, and molecular chaperones was identified as frontier research topics. Biochemistry, multidisciplinary science, and cell biology have the highest betweenness centrality values of 0.60, 0.28, and 0.26, respectively. Multidisciplinary Chemistry (burst years: 2017 to 2023; strength = 6.3) was a subject involved in the research frontier of this field. Conclusion: Research on heat shock proteins in ophthalmology mainly focuses on revealing the genetic background of the diseases and exploring the molecular mechanisms and therapeutic applications in glaucoma and cataracts. The advance in the study on molecular mechanisms in this field depends on multidisciplinary collaboration.
Abstract：Objective: To evaluate the application of 20g Y-type venous indwelling needle self-made oil extractor combined with 20g flute needle in vitreous silicone oil extraction. Methods: retrospective analysis 98 patients (98 eyes) from 2018 to 2020 with stable retinal attachment 3 ~ 6 months after silicone oil filling after vitrectomy. Take out the silicone oil by a self-made oil extractor with pulling out the core of 20GY venous indwelling trocar, and then exchange gas - liquid with 20g flute needle for twice. Results: silicone oil removal time: 4 65±1.52min； Gas liquid exchange time: 20g group: 1 25±0. 51min； Intraocular pressure: before operation, 1 day, 4 days, 1 week and 1 month after operation: 14.23 ± 4.52mmHg, 8.33 ± 3.12mmHg, 9.54 ± 4.52mmHg, 12.46 ± 4.52mmHg and 15.36 ± 2.46mmHg; Complications: the infection rate was 0, the bleeding rate was 2 / 90 (2.22%), the recurrence rate of retinal detachment was 3 / 90 (3.33%), low intraocular pressure was 13 / 90 (14.44%), and foreign body sensation was 18 / 90 (20%); The residual rate of silicone oil is 4 / 90 (4.44%). Conclusion: the self-made oil extractor by pulling out the needle core of 20g Y-type venous indwelling needle combined with 20g flute needle take out the silicone，they are safe and effective，so It is deserved promotion in clinic 。
Objective：To observe the clinical effect of Runmu Xunyan Decoction with ultrasonic atomization in the treatment of dry eye. Methods：A total of 56 dry eye patients (112 eyes) diagnosed in Shanxi Provincial Eye Hospital from July 2020 to January 2021 were included，and use Runmu Xunyan Decoction ultrasonic nebulization and sodium hyaluronate eye drops separately.Both groups were treated for three courses of treatment. The subjective symptom score, tear river height, tear film breakup time, corneal fluorescein staining, Meibomian gland function score, lipid layer grading before and after treatment were observed in the two groups of patients before and after treatment for 10, 20, and 30 days. The change. Results: There were statistically differences in subjective symptom scores, TMH, and avNITBUT between the two groups before and after treatment within the group; There were statistically differences in subjective symptom scores, TMH levels at 20 and 30 days of treatment, and avNITBUT levels between the two groups after treatment; Intragroup comparison of corneal FL and meibomian gland scores between the two groups before and after treatment, and there was no statistically difference in corneal FL scores between the two groups after treatment; There was a statistically difference in lipid layer grading between the two groups before and after treatment in the ultrasound nebulization group, while there was no statistically difference in the sodium hyaluronate group; There was a statistically difference in meibomian gland scores between the two groups after treatment; The effective rate of the ultrasonic atomization group was 77.77%, and the effective rate of the sodium hyaluronate group was 58.62%. Conclusion：Ultrasonic atomization of Runmu Xunyan Formula can significantly reduce the subjective symptoms of dry eye patients, increase the height of the tear river, increase the average tear film breakup time, and improve the quality of the lipid layer.The clinical efficacy of ultrasonic atomization of Runmu Xunyan prescription in the treatment of dry eye is better than that of sodium hyaluronate eye drops, which is worthy of clinical application.
Glaucoma is a common ophthalmic condition, often associated with visual field defects and optic nerve damage. If left untreated, it can lead to permanent vision loss. In recent years, with the continuous advancement of artificial intelligence (AI) technology, its application in the field of ophthalmology has garnered increasing attention. Particularly, in the screening and diagnosis of glaucoma using fundus photographs, AI technology has shown tremendous potential. This section will review the progress of AI in utilizing fundus images for glaucoma screening and diagnosis.
Carbon dots or CDs is a new type of fluorescent carbon nanomaterial, which the diameter is generally less than 10 nm, has the advantages of self-fluorescence, remarkable biocompatibility, easy modification, low cost and so on, has a broad application prospect in the biomedical field. Local eye drops and vitreous drug injection (IVT) are the main modes of administration for ocular diseases. Due to the unique barrier structure of the eye, it is difficult for conventional drugs to reach the lesions through local eye drop administration, and for the drug residence time is short, patients have to increase the frequency of administration to maintain the drug efficacy. Up to now, the treatment of posterior eye diseases, such as diabetic macular edema (DME), choroidal neovascularization (CNV) and other diseases still rely on repeated vitreous injection, which is more traumatic, more side effects, and cause the heavier psychological and economic burden of patients. Optimizing the method of ocular drug delivery has always been a hot topic in the field of ophthalmology. Carbon dots have good permeability in the eye, showing excellent application potential in the ocular drug delivery, ocular imaging, and diagnosis and treatment of ocular disease. This review will systematically introduce the characteristics of carbon dots and the application of carbon dots and their nanomaterials in the biomedical field in the past ten years, focusing on the research progress of carbon dots in the diagnosis and treatment of eye diseases, aiming to provide a comprehensive understanding of the current situation of the application of carbon dots in ophthalmology and provide directions for future research.
Purpose: The aim of this study was to determine self-management and its association with self-efficacy and knowledgeamong glaucoma patients undergoing day surgery. Methods: A total of 223 glaucoma patients were recruited from September 2021 to May 2022，and they were investigated with the Glaucoma Self Management Questionnaire (GSMQ)，The Self-Efficacy in Chronic Disease Scale (SECD-6), and the glaucoma knowledge questionnaire. Results:Of the 223 study participants, the study population had a total GSMQ score of 54.03±6.95with the lowest score found in the life adjustment dimension. The total SECD-6 score was showing asignificantly positive correlation with the total GSMQ score（r=0.368, P＜0.001). The total score of disease knowledge was without significant correlation with the total GSMQ score (r=0.077, P=0.252). Multivariate linear regression analysis showed that self-efficacy and enducation level was independently associated with self-management (P<0.001, P=0.028).Conclusions:Glaucoma patients undergoing daytime surgery demonstrated good overall self-management, yet further improvement was required in terms of life adjustment. Low self-efficacy and educational level were identified as risk factors for self-management. Therefore, self-management programs should prioritize enhancing patients' self-efficacy and delivering individualized education.
To evaluate the application value of optos ultra-widefield imaging system in the preoperative screening of diabetic retinopathy (DR) in older cataract patients with diabetes mellitus
Dry eye syndrome is a common ocular complication of type 2 diabetes mellitus, which often brings a lot of troubles to patients' life and work. With the increase of the prevalence of type 2 diabetes, there are more and more patients with dry eye in clinic, which has attracted more and more attention of medical workers. In recent years, the research on type 2 diabetes combined with dry eye is increasing, which provides a certain clinical basis for better treatment of this disease. This review will be divided into "modern medical cognition" and "traditional Chinese medicine cognition" two sections, on the definition, diagnosis methods, influencing factors, pathogenesis and treatment and other aspects of a comprehensive exposition.
