Affiliations

1.Cambridge Centre for Brain Repair, Department of Clinical Neurosciences, and MRC Mitochondrial Biology Unit, University of Cambridge

2.Cambridge Eye Unit, Addenbrooke’s Hospital, Cambridge University Hospitals

3.Moorfields Eye Hospital and UCL Institute of Ophthalmology, London

Professor Yu-Wai-Man is an academic neuro-ophthalmologist with a major research interest in mitochondrial genetics and inherited eye diseases. He holds a tenured Faculty position as Chair of Ophthalmology at the University of Cambridge, affiliated with the Cambridge Centre for Brain Repair and the MRC Mitochondrial Biology Unit. In addition to his academic roles, he has joint clinical appointments at Addenbrooke’s Hospital in Cambridge and Moorfields Eye Hospital in London as an Honorary Consultant Neuro-Ophthalmologist.

Professor Yu-Wai-Man’s research group is exploring the disease mechanisms leading to progressive retinal ganglion cell loss in inherited optic neuropathies by using a combination of patient tissues, induced pluripotent stem cells and animal models. He was awarded a prestigious NIHR Advanced Fellowship (2021-2026) to evaluate patient outcomes and therapies for this group of disorders.

Professor Yu-Wai-Man is the Director of the Cambridge Clinical Vision Laboratory (CCVL) that was set up as a cross-cutting facility to support advanced therapeutics on the Cambridge Biomedical Campus. In parallel, he has established a strong collaborative link with the NIHR Moorfields Biomedical Research Centre to fast track the development of effective therapies for inherited optic neuropathies, including novel gene therapy approaches. With funding from the NIHR and the MRC, he has built a national referral network for the investigation and management of patients with mitochondrial eye diseases. His research group is capitalising on this unique resource to explore disease biomarkers and the clinical applicability of high-resolution structural and functional imaging (eye and brain).