阿尔茨海默病(Alzheimer’s disease，AD)是发生于老年期或老年前期的中枢神经系统退行性病变，以进行性认知功能障碍为特征。随着社会老龄化加剧，AD已成为全球公共卫生问题，亟需研发更敏感、便捷和经济的筛查技术进行早期防控。眼球运动与认知功能密切相关，且眼球运动检查有非侵入性、成本低、检查时间短等优点。研究眼球运动异常和认知功能障碍之间的相关性，有助于研发更简便易操作的认知功能障碍筛查工具。随着人工智能技术的发展，机器学习算法强大的特征提取和计算能力对处理眼球运动检查结果有显著优势。本文对既往AD患者与眼球运动异常之间的相关性研究进行综述，并对机器学习算法模型辅助下，基于眼球运动异常模式进行认知功能障碍早期筛查技术开发的研究前景予以展望。

Alzheimer’s disease (AD) is a degenerative disease of the central nervous system that occurs in old age or early old age. It is characterized by progressive cognitive dysfunction. With the world population aging, AD has become a global public health problem. The development of a more sensitive, convenient, and economic screening technology for AD is urgently needed. The eye movement function is closely related to cognitive function. Moreover, eye movement examination has advantages including non-invasiveness, low cost, and short examination time. Researches on the correlation between abnormal eye movement and cognitive dysfunction can help to develop a simple and easy-to-use screening tool for cognitive dysfunction. With the development of artificial intelligence technology, the dominant feature extraction and computing capabilities of machine learning algorithms have a significant advantage in processing eye movement inspection results. This article reviews the correlation between AD and eye movement abnormalities aiming to provide the research prospects of early screening technology development for cognitive dysfunction based on abnormal eye movement with the application of machine learning models.

球后阻滞是眼科手术中常见的麻醉方式之一，若操作不当，可造成严重并发症，包括局部麻醉药物的毒性反应等。现报告1例26岁诊断为“视网膜脱离”拟行眼底手术的女性患者，在球后阻滞10min后，患者出现心率增快、血压升高后下降、吞咽困难、声音嘶哑、呼吸困难及SpO2下降，伴随对侧眼球运动障碍，全身肌力下降等临床表现。及时给予生命支持等对症处理后，患者上述临床表现好转，并随后在全身麻醉下完成手术。

Retrobulbar block is one of the common anesthesia methods in ophthalmic surgery, however, misconducting the procedure would result in severe complications including central toxicity from local anesthetics. This study presented a 26-year-old female patient diagnosed retinal detachment for retinal surgery under retrobulbar block, 10 min after anesthesia, the patient initially exhibited increased heart rate and blood pressure, inability to swallow secretions (sputum), hoarseness, and dyspnea, then SpO2 decreased, the patient displayed contralateral eye movement disorder, reduced systemic muscle strength and other clinical manifestations. The condition was improved with the treatments for life support, and the surgery completed uneventfully under general anesthesia with tracheal intubation.