Review Article
Original Article

Objective electrophysiological contrast sensitivity with monofocal and multifocal intraocular lenses: a prospective clinical study

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Background: To compare objective electrophysiological contrast sensitivity function (CSF) in patients implanted with either multifocal intraocular lenses (MIOLs) or monofocal intraocular lenses (IOLs) by pattern reversal visual evoked potentials (prVEP) measurements.

Methods: Fourty-five cataract patients were randomly allocated to receive bilaterally: apodized diffractive-refractive Alcon Acrysof MIOL (A), full diffractive AMO Tecnis MIOL (B) or monofocal Alcon Acrysof IOL (C). Primary outcomes: 1-year differences in objective binocular CSF measured by prVEP with sinusoid grating stimuli of 6 decreasing contrast levels at 6 spatial frequencies. Secondary outcomes: psychophysical CSF measured with VCTS-6500, photopic uncorrected distance (UDVA), and mesopic and photopic uncorrected near and intermediate visual acuities (UNVA and UIVA respectively).

Results: Electrophysiological CSF curve had an inverted U-shaped morphology in all groups, with a biphasic pattern in Group B. Group A showed a lower CSF than group B at 4 and 8 cpd, and a lower value than group C at 8 cpd. Psychophysical CSF in group A exhibited a lower value at 12 cpd than group B. Mean photopic and mesopic UNVA and UIVA were worse in monofocal group compared to the multifocal groups. Mesopic UNVA and UIVA were better in group B.

Conclusions: Electrophysiological CSF behaves differently depending on the types of multifocal or monofocal IOLs. This may be related to the visual acuity under certain conditions or to IOL characteristics. This objective method might be a potential new tool to investigate on MIOL differences and on subjective device-related quality of vision.

Perspective

Degenerative myopia: mechanical theories revisited

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Abstract: The article discusses the early abandonment of mechanical theories about eye enlargement in degenerative myopia at the turn of the 20th century. At that time, the number of theories about myopia grew unrestricted, but with scant support from the experimental field. The mechanical theories vanished as a new wave of metabolism-based theories appeared, propelled by the huge advances in molecular biology. Modern techniques allow reconsidering those theories and to put them to test with higher confidence.

Visual Impairment and Rehabilitation

AB106. ORVIS: a directory of tools for vision rehabilitation

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Background: The ORVIS infrastructure aims to facilitate the development and availability of valid and adapted tools that will allow functional, perceptual, cognitive and psychological evaluation of low vision clients by researchers and clinicians who work in low vision and visual impairment rehabilitation.

Methods: The tools developed or documented within ORVIS Infrastructure are tests or questionnaires which allow, or will allow to assess—in an accurate and reliable manner—characteristics related to visual impairment. The tools in development are: (I) questionnaire de repérage des hallucinations visuelles liées au syndrome de Charles-Bonnet (QR-SCB); (II) repérage des personnes agées présentant des INDices de déficience VISUELle (IndiVisuel); (III) mesure de l’impact de la déficience visuelle dans les activités quotidiennes (MIDVAQ) and (IV) M’EYE read test. The directory documents 14 tools and offers—within a descriptive sheet—characteristics, components and metrological properties as supported by cited scientific studies.

Results: The ORVIS Infrastructure, which aims at the development and availability of assessment tools, fills researchers’ and clinicians’ needs for measurement tools that are valid, effective and appropriate for use with a visually impaired clientele. Such tools are, especially in French, little known and hard to find, and represent a precious resource for those who want to evaluate the efficacy of treatments or interventions.

Conclusions: ORVIS is available at www.orvis.vision. Between November 2015 and September 2017, the directory has been accessed 1,383 times by 952 unique visitors.

Visual Impairment and Rehabilitation
Visual Impairment and Rehabilitation

AB105. Database of retinal images in visually impaired individuals: drusen and age-related macular degeneration (AMD)

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Background: With a large portion of older adults living longer, the number of individuals diagnosed with low vision is increasing. The use of optical coherence tomography/scanning laser ophthalmoscope (OCT/SLO) to diagnose retinal disease has become common place in the last 10 years, yet currently there are no OCT/SLO databases for pathological vision. Our aim is to develop a clinical database of individuals who have drusen (i.e., lipid deposits found under the retina), or have been diagnosed with age-related macular degeneration (AMD), with information as to how the structure of the diseased retina changes over time, as well as measures of visual and cognitive functional performance.

Methods: Fundus photographs and retinal scans will be taken using the same model of optos OCT/SLO located in three test sites (MAB-Mackay Rehabilitation Centre, School of Optometry Clinic at the University of Montreal, and the Lighthouse Institute, New York, USA). For each individual entry in the database, demographic and diagnosis information will be available. All OCT/SLO images will be graded according to the Age-related Eye Disease Study standard, in addition to number and size of drusen, severity of geographic atrophy, severity of pigment mottling and presence of choroidal neovascularization. Retinal topography and Raster scans from the OCT/SLO will provide a cross-sectional look at affected retinas. Fixation stability will be recorded using the SLO function, and present four different tasks that are designed to reproduce typical tasks of daily vision, with each task lasting for 10 seconds. The tasks are cross fixation, face recognition, visual search, and reading. These tasks in addition to the retinal scans will be used to determine the eccentricity of a preferred retinal locus from the anatomical fovea, and can be used as an outcome measure for clinical interventions in visually impaired patients.

Results: The database will be available to professors training eye-care practitioners and rehabilitation specialists as a teaching tool. Students will be able to familiarize themselves with the retina and a variety of AMD-related pathologies before they start working with patients. The database will also be accessible by researchers interested in studying AMD from basic science to epidemiology, to investigate how drusen and AMD impact visual and cognitive functional performance.

Conclusions: The common infrastructure is easily accessible to all VHRN members on request. The database will also be accessible online in 2018 (see http://cvl.concordia.ca for more information).

Visual Impairment and Rehabilitation
Visual Impairment and Rehabilitation

AB103. Comparative study on the actual lighting assessment method and the use of a standardized tool (LuxIQTM)

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Background: With the arrival of a new standardized tool and considering the multiple disadvantages of the actual method used for assesses lighting needs, the goal of the study was to compare the actual lighting assessment method used by the clinicians working in a rehabilitation center with the use of the LuxIQTM. As reading is found to be the main difficulty mentioned by the majority of the clients at the rehabilitation centre and that past studies have shown the impact of lighting on improving reading speed and deceasing print size, the hypothesis stated that the use of the standardized tool would be statistically significantly superior than the use of the standard method on the variables on reading speed, print size, ocular fatigue, application of the recommendations and satisfaction of the length of time read.

Methods: Three clinicians proceeded to home lighting assessments for 28 participants aged from 19 to 100 years (mean =75, SD =27) old diagnosed with age-related macular degeneration or glaucoma. The study evaluated and compared pre and post results between the two methods.

Results: The intervention did not have a statistically significant impact on any of the variables mentioned. The lighting assessment itself, with either the standard method or using the LuxIQ, statistically significantly decreased print size for reading (P<0.001, ω2 =0.47).

Conclusions: Lighting has a significant impact on reading print size. Participants value the assessment but encounter various obstacles that prevent them from applying the lighting recommendations. Considering the positive impact of lighting, finding a solution so participants may profit from the benefits of this intervention is crucial.

Visual Impairment and Rehabilitation

AB102. Image blur perception in amblyopia: beyond edges

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Background: Understanding the neurophysiological mechanisms of Amblyopia, a neurodevelopmental disorder of the visual cortex, will bring us closer to full recovery. Past findings have been contradictory. Results have shown that despite having severe acuity impairment, amblyopes can nonetheless perceive sharp edges. In this study, we explore the representation of blur through a series of image blur-discrimination and matching tasks, to understand more about the amblyopes’ visual system.

Methods: Monocular image blur-discrimination thresholds were measured in a spatial two-alternative forced-choice procedure whereby subjects had to decide which image was the blurriest. Subjects also had to interocularly match pictures that were identical to those used for the image blur discrimination task. Ten amblyopes, as well as a group of ten controls were under study.

Results: Data on amblyopes and controls will be presented for both experiments. According to previous research that was done on blur-edge discrimination and matching, we predict that subjects’ performance will follow a dipper function, that is, all observers will be better at discriminating between both images when a small amount of blur is applied rather than when the image is either sharp or very blurry. We also predict that amblyopes’ blur discrimination will be noisier, but that they will paradoxically be able to match the sharpness of the images presented in the matching task.

Conclusions: This would confirm our hypothesis about amblyopes’ visual system, that they can represent blur levels defined by spatial frequencies that are beyond their resolution limit, and would also raise interesting questions about the visual system in general regarding the different perceptions driven by images versus edges.

Visual Impairment and Rehabilitation

AB100. Screening for vision and hearing loss in patients with dementia: recommendations from interviews with sensory experts

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Background: Dementia is a syndrome that affects a person’s ability to understand and express information. The higher prevalence of vision and/or hearing losses among persons with dementia in long-term care (LTC) facilities interferes with the ability of nurses to provide optimal care because communication is compromised. Therefore, the detection and screening for sensory impairment is of the utmost importance in LTC facilities; however, there is currently no agreement among nursing professionals on how to best identify such losses for the purpose of further referral, and the need for a validated screening measure suitable for nurses in LTC facilities is clear. The present project aims to close this gap by investigating the screening recommendations of vision- and hearing-care professionals working with clients affected by dementia.

Methods: Eleven experts in audiology, optometry, deafblindness, and technology participated in individual semi-structured interviews on the topic of tools and strategies that can be used to screen individuals with dementia for sensory loss. Interview transcripts were coded by two evaluators using verbal agreement and consensus building.

Results: Three main themes emerged from the interviews with experts: barriers, facilitators, and strategies. Barriers to sensory screening were often mentioned, particularly impaired communication and lack of staff cooperation. Facilitators consisted uniquely of people, such as family members, intervenors, and nurses. Strategies for sensory screening in this population consisted of improving communication through repetition and encouragements; considerations based on familiarity; and inferring an impairment on the basis of patient behaviour. Few of our interviewees were knowledgeable on the topic of screening apps.

Conclusions: Our findings, to be integrated with a similar environmental scan conducted among LTC nurses, can inform the administration of sensory impairment screening tests among a population with dementia in order to optimize care.

其他期刊
  • 眼科学报

    主管:中华人民共和国教育部
    主办:中山大学
    承办:中山大学中山眼科中心
    主编:林浩添
    主管:中华人民共和国教育部
    主办:中山大学
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  • Eye Science

    主管:中华人民共和国教育部
    主办:中山大学
    承办:中山大学中山眼科中心
    主编:林浩添
    主管:中华人民共和国教育部
    主办:中山大学
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