Abstract: Retinal degeneration, a leading cause of irreversible blindness, often results from photoreceptor deterioration due to genetic mutations or damage to retinal pigment epithelial (RPE) cells. Emerging research highlights the gut-eye axis, a connection between gut microbiota and eye diseases. Our recent findings demonstrate that bacterial translocation from the gut to the retina contributes to Crb1-associated retinal degeneration. This review explores the relationship between the gut microbiome and retinal degeneration, focusing on inherited retinal degeneration (IRD) and age-related macular degeneration (AMD).
