论著

白内障手术患者围手术期非甾体抗炎滴眼液使用合理性分析

Analysis of the rational use of nonsteroidal antiinflammatory eye drops in perioperative patients undergoing cataract surgery

:515-521
 
目的: 探讨白内障手术患者围手术期非甾体抗炎药(non-steroidal anti-inflammatory drugs, NSAIDs)滴眼液应用的合理性,为优化临床用药方案提供依据。方法:采用回顾性研究方法,分析郑州市第二人民医院2024年100例(100眼)行白内障超声乳化并人工晶状体植入手术患者的临床数据,依据药品说明书、《我国白内障围手术期非感染性炎症反应防治专家共识(2015年)》《中国成人白内障摘除手术指南(2023年)》《中国激光角膜屈光手术围手术期用药专家共识(2024年)》等指南/共识制定评价标准,评价NSAIDs滴眼液的用药频次、疗程及术前预防性抗炎处理的规范性。结果:35%的病例存在用药不合理,共发现88项问题,包括用药频次错误(7.96%)、超疗程(22.72%)及术前用药不当(69.32%)。其中,65%糖尿病患者术前未启动NSAIDs预处理,41%非糖尿病患者术前1 d使用NSAIDs;溴芬酸钠滴眼液疗程超过10天者占20.45%,可能增加肝损伤风险。结论:医疗机构应采取积极有效措施,如制定个体化用药方案、加强合理用药培训、开展专项处方点评等,切实促进NSAIDs滴眼液在白内障手术患者围手术期的合理使用,保障患者的用药安全与治疗效果,提高医疗服务质量和患者满意度。
Objective: To investigate the rationality of perioperative application of non-steroidal anti-inflammatory drugs (NSAIDs) eye drops in patients undergoing cataract surgery, thereby providing evidence for optimizing clinical medication protocols. Methods: A retrospective study method was used to analyse the clinical data of 100 patients (100 eyes) who underwent cataract ultrasonoemulsification with IOL implantation in 2024 at the Second People's Hospital of Zhengzhou City, and the evaluation criteria were developed based on the instructions of the medication, the Chinese expert consensus on prevention and management of non-infectious inflammatory responses in the perioperative period of cataract surgery (2015), the Chinese guideline for cataract surgery in adults (2023), and the Chinese expert consensus on the perioperative medication in laser corneal refractive surgery(2024)" and other guidelines/consensus to develop evaluation criteria to evaluate the standardisation of NSAIDs eye drops in terms of frequency of dosing, duration of treatment, and preoperative prophylactic anti-inflammatory treatment. Results: Irrational medication use was identified in 35% of cases, with a total of 88 issues categorized as follows: incorrect dosage frequency (7.96%), prolonged treatment duration (22.72%), and inappropriate preoperative medication (69.32%). Notably, 65% of diabetic patients failed to initiate NSAIDs pretreatment preoperatively as recommended by guidelines, while 41% of non-diabetic patients received NSAIDs one day before surgery. Prolonged use of bromfenac eye drops (>10 days) was observed in 20.45% of cases, potentially increasing the risk of liver injury. Conclusions: Medical institutions should take active and effective measures, such as formulating individualised medication plans, strengthening training on rational use of medication, and carrying out special prescription reviews, etc., to effectively promote the rational use of NSAIDs eye drops in the perioperative period of patients undergoing cataract surgery, to safeguard the safety of patients' use of medication and therapeutic efficacy, and to improve the quality of healthcare services and patients' satisfaction.
其他期刊
  • 眼科学报

    主管:中华人民共和国教育部
    主办:中山大学
    承办:中山大学中山眼科中心
    主编:林浩添
    主管:中华人民共和国教育部
    主办:中山大学
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  • Eye Science

    主管:中华人民共和国教育部
    主办:中山大学
    承办:中山大学中山眼科中心
    主编:林浩添
    主管:中华人民共和国教育部
    主办:中山大学
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