目的：比较水合氯醛和阿佛丁两种药物对小鼠的麻醉作用以及不同激光能量对脉络膜新生血管造模成功率的影响。方法：24 只C57/BL6 小鼠随机分为 3 组，分别予以 200，300 和400 mW的 532 nm激光进行视网膜光凝；每组再按 1:1 分为 2 个亚组，随机使用 4.3%水合氯醛或 1.2%阿佛丁进行小鼠腹腔注射麻醉。在激光光凝后第 4，7，10 和 14 天进行视网膜荧光素造影（Fundus Fluorescein Angiography，FFA）、SD-OCT检查，在第 14 天时对脉络膜行IB4 染色检查。结果：阿佛丁和水合氯醛诱导小鼠进入麻醉时间长分别为（120±30）s和（150±45）s，持续时间分别为（30±15）min和（50±20）min，差异均有统计学意义（均P=0.0001）；发生不可逆性白内障的比率分别为 2/24 和 1/24 ，麻醉导致的死亡数分别为1和0只，差异均无统计学意义（P=0.551，P=0.300）。200，300 和 400 mW三个激光能量组的造模成功率分别为 9.38%，37.5%和 93.75%，差异有统计学意义（P=0.0001）。FFA显示：造模成功的小鼠在4d时荧光素渗漏达到高峰，随后荧光素溢漏的面积逐渐减小。结论：与阿佛丁相比，水合氯醛对小鼠的麻醉维持时间长且不会增加病死率和不可逆性白内障的发生率； 400 mW的 532 nm激光能量是诱发CNV的较好设置。

Objective: To compare the narcotic effects of chloral hydrate and avertin in mouse models and the success rate of choroidal neovascularization (CNV) mouse model establishment with different energy hierarchy of laser.Methods: Twenty-four mice were randomized into 3 groups, the 532 nm laser was used with different power levels of 200, 300 and 400 mW for each group. In each group, the chloral hydrate was used for 4 mice and avertin for the other 4 mice at random. On day 4, 7, 10 and 14, all mice were tested by the fundus fluorescein angiography (FFA), SD-OCT, and the choroid was stained with the isolectin B4 conjugated AF488 on day 14. Results: The anesthesia induction time of avertin and chloral hydrate was （120±30） s and（150±45）s, and the duration of anesthesia was （30±15）min and （50±20） min, the differences were statistically significant （all P=0.0001）; the incidence of irreversible cataract of avertin models and chloral hydrate models was 2/24 and 1/24, the number of death in two models was 1 and without statistical significance （P=0.551, P=0.300）. With the increase of laser energy, the success rate of experiments was also gradually increased, from 9.38%, 37.5% to 93.75% （P=0.0001） in 200, 300 and 400 mW group, respectively. According to the results of FFA, the peak of fluorescence leaking was at day 4 after the laser burning, and was gradually reduced. Conclusion: Compared with avertin chloral hydrate can improve the duration of anesthesia without increasing the risk of cataract and mortality. As for the 532 nm laser,the 400 mW energy could be an optimal parameter for the laser-induced CNV.

目的：探讨术区旁角膜缘上皮移植治疗翼状胬肉的手术方法和临床效果。方法：对 69 例（ 82 眼）翼状胬肉行术区旁角膜缘上皮移植术，随访 1 年，观察手术效果。结果： 79 眼（96.34%）临床治愈， 3 眼（3.66%）复发。结论：术区旁角膜缘上皮移植治疗翼状胬肉是较好的手术方法。

Objective: To investigate the operation method and clinical effect of modified pterygium excision with limbalconjunctival flap grafting beside the operation area. Methods: Excision of pterygium and limbal conjunctival autografting were performed on 82 eyes of 69 cases. The surgical effects were observed after 1 year of follow-up. Results: A total of 79 eyes （96.34%） were cured and 3 eyes （3.66%） recurred. Conclusion: Modified pterygium excision with limbal-conjunctival flap grafting beside the operation area is a efficacious method in the treatment of pterygium.

      视网膜中央动脉阻塞（central retinal artery occlusion，CRAO）是一种严重致盲性眼病。糖尿病性视网膜病变玻璃体切除联合眼内光凝术后中央动脉阻塞的临床表现及预后有其特点。南通大学附属医院收治的 2 例糖尿病性视网膜病变患者在经过玻璃体切除联合眼内光凝术后出现 CRAO。本文通过回顾 2 例患者的临床病例资料，讨论及分析其 CRAO 的原因、危险因素及诊疗方法。

Central retinal artery occlusion (CRAO) is a severe eye disease causing blindness. The clinical manifestations and prognosis of posterior artery occlusion after vitrectomy combined with intraocular photocoagulation for diabetic retinopathy are specific. Two patients with diabetic retinopathy in Affiliated Hospital of Nantong University developed central retinal arterial occlusion after vitrectomy combined with intraocular photocoagulation. In this article, the clinical data of two patients with CRAO were retrospectively analyzed. The causes, risk factors, diagnosis and treatment of CRAO were analyzed.

      睑缘炎相关性角结膜病变（Blepharo Kerato conjunctieitis，BKC）是临床上容易误诊的一类疾病，其治疗方法也多集中于激素治疗，病情易反复，毒副作用多。中医综合疗法不仅方法灵活多变，疗效可靠，长期使用无不良反应，患者乐于接受，符合“易、便、灵、验”的原则，是目前治疗本病最安全有效、便利的方法。本研究通过分析小柴胡汤内服联合中药塌渍和刺络放血治疗 1 例肝胆火炽证 BKC 的治疗，探究其机制及疗效。经治疗后患者睑缘炎症消除，角膜云翳消退，视力提高，全身情况也得到良好改善。采用中医特色综合治疗，能安全有效地控制病情发展，极大降低因治疗带来的二次伤害，最大程度提高患者康复概率。

Blepharokeratoconjunctivitis (BKC) is easily misdiagnosed in clinical practice and hormone therapy is frequently chosen. The high recurrence rate of BKC causes multiple side effects. However, Chinese herbal therapy yields slight adverse events and it can be given for a relatively long period of time. In this study, one BKC patient with liver and gallbladder fire syndrome was given with Xiaochaihu decoction, Chinese medicine sloughing combined with bloodletting puncture. Comprehensive treatment combined with Chinese medicine sloughing can safely and effectively prevent the progression of BKC, significantly reduce the secondary injury induced by treatment, and accelerates the recovery of the patients.

目的：比较急性闭角型青光眼（acute primary angel-closure glaucoma，APACG）患者在瞳孔散大、瞳孔缩小、瞳孔正常状态下前房形态变化。方法：选取 APACG 患者 81 例 81 眼，在瞳孔散大（Time1）、瞳孔缩小（Time2）、瞳孔正常（Time0）状态下，分别用 Pentacam 测量前房容积（anterior chamber volume，ACV）、中央前房深度（central anterior chamber depth，CACD）、周边前房深度（peripheral anterior chamber depth，PACD）、前房角角度（anterior chamber angle，ACA），并将这些前房参数进行对比分析。结果：与 ACV0 相比，ACV1 ，ACV2 均减小，而 ACV2 较 ACV1 增加（P<0.01）；CACD0 ，CACD1 ，CACD2 间差异无统计学意义（P>0.01）；与 PACD0 相比，PACD1 明显减小，PACD2 明显增加，PACD2 较 PACD1 显著增加（P<0.01）；与 ACA0 相比，ACA2 明显增加（P<0.01），ACA1 变化差异无统计学意义（P>0.01）；ACA2 与 ACA1 差异无统计学意义（P>0.01）。结论：PCAD，ACV 是反映 APACG 患者瞳孔大小变化时前房形态敏感指标；患者停用毛果芸香碱眼液后 ACV 增加证实缩瞳剂并不适合长期使用。

Objective: To observe the changes of anterior chamber morphology in mydriasis （Time1）, miosis （Time2） and normal pupil （Time0） of acute primary angel-closure glaucoma （APACG） patients using Pentacam. Methods: Eighty-one eyes in 81 patients with APACG, aged 51 to 79 years, were included in this study. All subjects with different pupil sizewere evaluated by Pentacam. We measured the anterior chamber volume （ACV）, central anterior chamber depth （CACD）, peripheral anterior chamber depth （PACD） and anterior chamber angle （ACA）. The Pentacam metrics were compared in three different pupil size under different conditions. Results: ACV1 and ACV2 were significantly lower than ACV0, whereas ACV2 was significantly higher than ACV1 （both P<0.01）. CACD showed no significant changes under different conditions （P>0.01）. Compared with PACD0, PACD1 was significantly decreased, PACD2 was increased and PACD2 was significantly higher than PACD1. ACA2 was significantly higher than ACA0 （P<0.01）. ACA1 did not change significantly. No significant difference was found between ACA2 and ACA1 （P>0.01）. Conclusion: PCAD and ACV are sensitive parameters to reflect the changes of anterior chamber morphology in three different pupil size of APACG patients, long-term use of pilocarpin eyedrops is not suitable for APACG patients.

目的：通过运用现代物联网技术，实现构建覆盖眼视光诊疗和验光配镜、医疗器械和耗材采购等多流程、多业务、多体系的眼视光综合管理信息系统。方法：依托现有移动互联网、云平台和现代物联网等技术，在传统眼科医疗信息系统技术基础上，上下延伸覆盖物流采购、仪器设备互联互通、移动支付和数据挖掘等业务流程和功能，推进眼视光管理综合运营。结果：实现供应链和物流全流程，眼视光门诊业务全流程，移动支付全流程，数据采集到数据挖掘全流程。结论：系统优势在于建立了一套完整的患者视光健康档案，为集团化视光产业走可持续发展道路提供优势资源。

Objective: To establish a multi-process,-service and –system integrated optometry information system, which covers optometry service, medical equipment and consumable procurement. Methods: Depending upon the Internet, cloud platform and Internet of things, the work flows integrating logistics procurement, equipment connection, mobile payment and data acquisition were achieved to promote the comprehensive management of optometry service on the basis of original information system for ophthalmic hospital. Results: The full-flow process was realized in the sessions of supply chain and logistics, optometry outpatient service, mobile payment, data acquisition, etc. Conclusion: The highlight of this system is to establish complete database for patients admitted to the optometry outpatient, which offer data and evidence for sustainable growth of optometry service.

      近视的患病率逐年增长，尤其是在东亚国家的人群中发病率高，现已经成为一个备受关注的公共健康问题。近视所造成的危害不容忽视，随着近视的形成和加重，可引起不同程度的视网膜和脉络膜的改变及损害。

The prevalence of myopia is increasing year by year, especially in East Asian countries. It has become a public healthy issue of concern. The harm caused by myopia cannot be ignored. With the formation and aggravation of myopia, different degrees of retinal and choroidal changes and damage can be caused.

目的：研究调节抑制对不同单色光中豚鼠眼屈光发育的作用。 方法： 根据光照不同将豚鼠分成 蓝光组（430 nm）、绿光组（530 nm）和白光组（色温 5 000 K），每组各 8 只。各组豚鼠右眼均点1%阿 托品滴眼液，每天1 次，持续6 周。实验前后各测一次屈光度、角膜曲率半径以及眼轴各参数。 结果： 实验前各组豚鼠双侧眼间及组间同侧眼屈光度差异无统计学意义（ 约4.25 D，P> 0 . 05） 。 但实验结束时蓝光组和绿光组双侧眼间屈光度差异显 （P = 0.0003 和 P= 0 . 028） ，而白光组双侧眼 间无显著差异（P = 0.7486）。实验结束时各组左眼（P < 0.05）、绿光组和白光组右眼（P= 0.001）以及蓝 光组和绿光组右眼（P < 0 . 001） 屈光差异有统计学意义。蓝光组和白光组右眼屈光差异无统计学意义 （P= 0 . 072） 。实验开始时各组双侧眼间及各组间同侧眼玻璃体腔长度差异无统计学意义 （ 约3.2 mm，P >0.05） 。实验结束时，蓝光组和绿光组双侧眼间玻璃体腔长度差异有统计学意义 （P = 0.00 17 和P = 0 . 01 13） ，但白光组双侧眼间差异无统计学意义（P = 0 . 93 71） 。同时，各组间同侧眼 玻璃体腔长度差异有统计学意义（P < 0 . 01） 。此外，实验前后各组双侧眼间及组间同侧眼角膜曲率 半径、前节长度、晶状体厚度差异无统计学意义（P >0.05） 。结论： 1% 阿托品加强 530 nm单色光促 进豚鼠眼玻璃体腔延长和近视形成的作用，但减弱 430 nm单色光抑制豚鼠眼玻璃体腔延长和远视 形成的作用。眼调节反应可能参与了单色光中豚鼠眼的屈光发育机制。阿托品影响单色光中豚鼠 眼屈光发育的作用可能是通过抑制眼调节反应实现的。

Objective: To investigate the effect of  inhibiting accommodation on ocular refractive development of guinea pigs in different monochromatic lights. Methods:Twenty-four pigmented guinea pigs were randomly divided intothree groups with 8 animals per group: short-wavelength light （SL, 430 nm） group, middle-wavelength light （ML, 530 nm） group and broad-band light （BL, 5 000 K color temperature） group. The right eyes of all animals were treated by 1% Atropine solution once a day for 6 weeks. Measurements of ocular refraction, corneal curvature, and axial length were performed at the start and the end of  the study. Results: There was no significant difference in bilateral ocular refraction for all groups at the beginning of the experiment （about 4.25 D, P>0.05） and in  ipsilateral ocular refraction among groups at the start of the experiment （P>0.05）. But at the end of the experiment, significant differences were detected between binocular refraction of the ML group （P=0.028） and the SL group （P=0.0003）, however, there was no significant difference between bilateral refraction in the BL group （P=0.7486）. There were significant differences in refraction between the left eyes of any two groups （P<0.05）, between the right eyes of  the ML and BL group （P=0.001）, and between the right eyes of  the ML and SL （P<0.001） at 6 weeks. No significant refractive difference was detected between the right eyes of the SL and BL groups （P=0.072）. The vitreous length was about 3.2 mm in bilateral eyes of all groups at the onset of  the experiment （all inner- or inter- group P>0.05）. After the experiment, the bilateral difference in vitreous length was significant in the ML group （P=0.0113） and the SL group （P=0.0017）, but not significant in the BL group （P=0.9371）. There were significant vitreous differences in right or left eyes among the groups at the end of the experiment （P<0.01）. There were no significant inter-group （ipsilateral） or inner-group （bilateral） differences at any time in any of corneal radius of curvature, anterior segment length and lens thickness （P>0.05 for all comparisons）. Conclusion: 1% atropine can strengthen the effect of vitreous elongation and myopic formation on guinea pig eyes in 530 nm monochromatic light. Moreover, atropine can weaken the effect of vitreous shortening and hyperopic formation on guinea pig eyes in 430 nm monochromatic light. Ocular accommodation response should involve in the mechanism of refractive development of guinea pig in monochromatic light. Atropine can influence the refractive development of guinea pig in monochromatic light possibly by inhibiting accommodation response.

栏目导读：为进一步满足期刊发展需求、活跃学术氛围、增强本刊的互动性和艺术性， 本刊特面向社会公开征集 《眼科学报》封面艺术画或摄影作品。被选中的作品，将以“封面故事”专栏的形式，或展示作品背后的精彩瞬间、 或抒发医者仁心的艺术情怀。

目的：总结 132 例穿透性角膜移植手术患者日间手术的护理的方法。方法：132 例穿透性角膜移植患者通过门诊的术前检查，术前解释，有角膜材料时通知入院，在日间病房给予责任制整体护理运行模式、医护一体化、家属同步健康教育、安全管理等全程优质护理服务。结果：132 例穿透性角膜移植患者顺利进行日间手术，患者如期出院。结论：结合运用责任制整体护理运行模式、医护一体化、家属同步健康教育、安全管理等护理模式对穿透角膜移植术患者进行日间手术护理，术程顺利，既缩短了手术等待时间，又降低了住院费用，得到了满意的效果。

Objective: To summarize the nursing methods of patients undergoing penetrating keratoplasty in day ward. Methods: A total of 132 cases of penetrating keratoplasty were examined and communicated before operation. The patients were notified if the corneal material was prepared. The overall primary nursing mode, the integration of medical care and nursing, the synchronous health education of the family and the safety management were provided in day ward. Results: All cases of penetrating keratoplasty were successfully managed by day surgery. The patient was discharged on schedule. Conclusion: The penetrating keratoplasty patients are managed by the overall primary nursing mode, the integration of medical care and nursing, the synchronous health education of the family and the safety management in day ward. It shortens the time for the patients to wait for the operation, reduces the cost of medical treatment and saves medical resources.