目的：探讨内窥镜下泪囊鼻腔吻合术联合泪道扩张引流管治疗复发性慢性泪囊炎的治疗效果及其应用价值。方法：选择齐齐哈尔市五官医院治疗的复发性慢性泪囊炎患者 26 例作为研究对象，随机分为观察组与对照组，对照组采用外路泪囊鼻腔吻合手术治疗，观察组采用内窥镜下泪囊鼻腔吻合术联合泪道扩张引流管治疗，记录治疗效果。结果：观察组总有效率为 92.30%；对照组总有效率为 69.23%，观察组临床治疗总有效率高于对照组，差异有统计学意义（P < 0.05）。结论：采用内窥镜下泪囊鼻腔吻合术联合泪道扩张引流管综合治疗复发性慢性泪囊炎手术成功率高，手术创伤小，术后皮肤无瘢痕，手术及住院时间短，值得在临床上推广使用。

Objective: To explore the therapeutic effect and application value of endoscopic dacryocystorhinostomy combined with dilated drainage tube for recurrent chronic dacryocystitis. Methods: A total of 26 patients with recurrent chronic dacryocystitis treated in our hospital were selected as the research subjects. The patients were randomly divided into the observation group and the control group. The control group was treated with external dacryocyst nasal anastomosis, and the observation group was treated by endoscopic dacryocystorhinostomy combined with lacrimal duct dilatation and drainage treatment. Results: The total effective rate of the observation group was 92.30%. The total effective rate of the control group was 69.23%. The total effective rate of the observation group was higher than that of the control group, and the difference was statistically significant (P<0.05). Conclusion: Endoscopic dacryocystorhinostomy combined with dilated lacrimal duct drainage tube has a high success rate in the treatment of recurrent chronic dacryocystitis, reducing the surgical wound is small and there is no scar on the skin after surgery, and the duration of the operation and hospitalization were short. It is worth popularizing in clinical practice.

目的：分析 1 个先天性晶状体脱位家系原晶状体原纤维蛋白 1（fibrillin-1，FBN1）基因突变的情况。方法：对 1 个单纯性晶状体脱位家系中的 25 位家族成员（包括 5 名患者）进行眼睛及全身临床检查。从外周静脉血抽提 DNA 进行 PCR 扩增反应，并对 FBN1 全部 65 个外显子进行测序分析。结果：在 5 位患者的核苷酸序列中均发现 FBN1 基因 c.1759 胸腺嘧啶突变为胞嘧啶。这个点突变导致 FBN1 蛋白第 587 号的半胱氨酸被精氨酸代替。结论：c.1759 胸腺嘧啶突变是导致患者晶状体脱位的 FBN1 基因突变位点，该结论进一步丰富了马凡综合征（Marfan syndrome，MFS）基因突变库，并有助于该家系中相关亲属的遗传咨询。

Objective: To identify the genetic defects of a family with inherited ectopia lentis. Methods: Among 25 family members, 5 patients underwent general physical and full ophthalmic examinations. Genomic DNA was extracted from leukocytes of venous blood of every family member. Polymerase chain reaction （PCR） amplification and Sanger’s sequencing of all exons of fibrillin-1 （FBN1） gene were analyzed. Results: A C>T mutation was identified at FBN1 nucleotide position c.1759. This mutation led to substitution of Cysteine for Arginine at condon 587. No FBN1 gene defects were found in any unaffected family member. Conclusion: We identified a mutation in FBN1. Our result expanded the mutation spectrum of FBN1 and also provided genetic counseling for the family relatives.

       患者，男，38岁，主因“右眼突然视力下降、视物变形 1 个月”就诊于河北省眼科医院。眼部检查：右眼视力 0.5，眼底黄斑区可见一个约 1/4 PD 的黄白色病灶，周围可见散在出血斑，毛细血管扩张，黄斑颞下方可见黄白色渗出。荧光素眼底血管造影+吲哚青绿血管造影（fluorescein angiography+indole green angiography，FFA+ICGA）示：可动态观察到黄斑区毛细血管扩张渗漏及晚期黄斑区的囊样水肿。光学相干断层扫描成像（optical coherence tomography，OCT）示：黄斑区局部神经上皮层隆起，呈囊样水肿表现。诊断：右眼特发性黄斑中心凹旁毛细血管扩张症（macular telangiectasia，MacTel）。中医辨证治疗，早期以清热凉血、健脾除湿为主；中期采用疏肝清热、健脾渗湿法；后期以补肾健脾为原则。治疗后，患者视力恢复正常，视功能明显改善，黄斑区水肿完全消退。随诊观察 4 年，患者病情控制良好。

The patient, male, 38 years old, was treated in Hebei Eye Hospital for the main cause of “sudden visual acuity of the right eye and visual deformity for 1 month”. Eye examination: visual acuity of the right eye was 0.5. A yellow-white lesion of approximately 1/4 diameter of visual nipple was seen in the macular area at the fundus of the eye. Around the macular area, there were scattered bleeding spots, telangiectasia, and yellow-white exudation was seen below the temporal lobe of the macula. Fluorescein angiography + indole green angiography (FFA+ICGA) showed that the telangiectasia leakage in macular area and cystic edema in late macular area was observed dynamically. Optical coherence tomography (OCT) showed local neuroepidermal bulges in macular area with cystic edema. Diagnosis: right eye idiopathic macular central fovea paravicular telangiectasia. Traditional Chinese medicine offer differentiation treatment, early to clear heat and cool blood, improve the function of spleen and dispel moisture; in the middle stage, the method of soothing liver and clearing heat and strengthening spleen infiltration; in the later period to invigorate the kidney and invigorate the spleen as the principle. After treatment, the patient’s vision returned to normal, visual function improved significantly, and the edema in the macular area completely subsided. After 4 years of follow-up, the patient’s condition was well controlled.

患者青年女性，工作时不慎从 4 m 高处跌落，伤后 1 周眼科检查时发现左眼上睑下垂、眼球固定、眼球突出、结膜下出血，复视，伤后 2 周进展为右眼结膜下出血水肿，并出现左侧搏动性血管杂音，进行全脑血管造影证实为左侧颈动脉海绵窦瘘，并予以介入海绵窦瘘栓塞术治疗，治疗效果满意后出院。

The patient, a young woman, was referred to ophthalmology department at 1 week after her falling from 4 meters high during her work. Her left eye was diagnosed with ptosis, eyeball fixation, exophthalmos, subconjunctival hemorrhage and diplopia. After 2 weeks, her conditions progressed to subconjunctival hemorrhage and edema of the right eye, with pulsatile vascular murmur on the left side. Left carotid-cavernous fistula was confirmed with digital subtraction angiography, and treated with interventional embolization. Satisfactory outcomes were obtained and the patient was discharged.

栏目导读：为进一步满足期刊发展需求、活跃学术氛围、增强本刊的互动性和艺术性，本刊特面向社会公开征集《眼科学报》封面艺术画或摄影作品。被选中的作品，将以“封面故事”专栏的形式，或展示作品背后的精彩瞬间、或抒发医者仁心的艺术情怀。

       患者女，54 岁，因“左眼视物模糊 4 个月余”入院，视力 0.5，虹膜表面可见大量棕色色素结节，且多数带蒂。房角镜下见下方、鼻侧及颞侧房角大量色素沉着。超声生物显微镜检查：左眼虹膜表面欠光滑并见多个高反射点。光学相干断层扫描：左眼见上方及下方视神经纤维层厚度变薄。用药后眼压：34 mmHg。诊断为 Cogan-Reese 综合征并继发性青光眼，予多种药物以降低眼压，无效后行复合式小梁切除术。术后 3 个月内随访，视力、视野保持稳定，眼压 8~20 mmHg。前房中深，滤过泡功能良好，视野显示 MD = –10.77 dB，局部未用降眼压药。抗青光眼手术能控制眼压防止病情进一步进展，但长期有效性仍需继续随访观察。

A 54-year-old woman presented to our department with complaints of blurred vision for more than 4 months in her left eye. Upon examination, the patient had best corrected visual acuity of 0.5 OS, intraocular pressure (IOP) OS was 34 mmHg after medication. On slit-lamp examination, there were multiple iris nodules, most of them pedunculated and intensively distributed in the inferior direction. On gonioscopic examination, a large number of pigments were noticed at the inferior, nasal and temporal direction. Fundus examination revealed glaucomatous cupping of 0.7. Optical coherence tomography showed marked loss of thickness of retinal nerve fiber layer fibers in the inferior, and superior direction. Based on the clinical features, the diagnosis of secondary angle closure due to Cogan-Reese syndrome was reached. As the medical therapy was ineffective, it was planned to go for surgical management in the form of trabeculectomy with 5-FU. At the 3-month follow-up, best corrected visual acuity OS was 0.5, IOP OS was 8–20 mmHg, the anterior chamber depth was medium and the filtering bleb was functional. A visual field was performed, which showed MD=–10.77 dB and the patient wasn’t given topical medication. A long-term follow-up is necessary because the disease itself is progressive in nature.

角膜损伤是眼科临床常见疾病，角膜愈合过程对视力恢复至关重要。角膜损伤后的愈合过程是多种细胞及细胞因子的共同作用，IL-6 在介导炎症反应及组织修复及角膜损伤修复过程中均发挥重要作用。

Corneal injuries are common in ophthalmology clinic, and corneal healing is critical for visual recovery. The healing process after corneal injury is the combined effect of various cells and cytokines. IL-6 plays an important role in mediating inflammatory response and tissue repair. In recent years, studies have shown that IL-6 plays an important role in the process of corneal healing.

      飞秒激光是一种以脉冲形式转运的红外线激光，可穿透透明组织，在组织内完成高精度切削，制作出不同形状的角膜植片和植床，在角膜移植方面取得了良好的应用效果。近年来多项相关研究阐述了飞秒激光辅助角膜移植术的有效性、安全性、稳定性，并提出一些新的技术和观点。

      Femtosecond laser is a kind of infrared laser transported in pulse form, and it can penetrate transparent tissue and perform high precision cutting in tissues. It can make corneal implants and beds with different shapes, and has achieved good results in corneal transplantation. In recent years, a number of related studies have described the effectiveness, safety and stability of femtosecond laser assisted keratoplasty, and have put forward some new techniques and viewpoints. 

药源性葡萄膜炎是一种较少见的疾病。尽管如此，九十年代在艾滋病患者中使用预防结核药物利福布丁而引发葡萄膜炎，加深了对药物在葡萄膜炎炎症发生中潜在作用的认识。以 Naronjo 建立的药源性疾病的诊断标准衡量，可以获知至少 120 种药物与葡萄膜炎发生相关，本文重点介绍其中最为常见的 7 类药物，包括抗骨质疏松类（二碳磷酸盐类），抗病毒类（西多福韦），抗结核药（利福布丁），抗青光眼药，眼内注射药，抗 TNFα 药物以及疫苗。了解这些常见的药源性葡萄膜炎药物，有利于临床识别这种特殊类型的葡萄膜炎。

Drugs induced uveitis is a rare disease. Nevertheless, uveitis induced by rifabutin which used as preventing tuberculosis drug in AIDS patients in 1990s, to some extent, enhance the knowledge of the potential effect of some drugs causing uveitis. According to the diagnostic criteria of drug-induced diseases developed by Naronjo, more than 120 drugs had been found to be related with uveitis. This review mainly introduces 7 common drugs, including anti-osteoporosis drugs （bisphosphonates）, anti-virus drugs （cidofovir）, anti-tuberculosis drugs （rifabutin）, anti-glaucoma drugs, intravitreal drugs, anti-TNFα antibody, and vaccines. Therefore, knowing the common known drugs can help better understand and distinguish the disease.

目的：比较过碘酸-Schiff 法（Periodic Acid-Schiff，PAS)，六亚甲基四胺银法（Grocott Methenamine silver，GMS），Gomori 氏氢氧化银氨法（Gomori）三种特殊染色方法显示角结膜原位癌基底膜完整性的优缺点，寻找较合适的染色方法。方法：选取中山大学中山眼科中心 2012 年 1 月至 2017 年 9 月期间收治的 20 例角结膜原位癌标本，分别采用 PAS、GMS、Gomori 三种染色，显微镜下观察角结膜原位癌基底膜显示状态。结果：三种染色方法都能显示角结膜原位癌基底膜，但其鲜艳程度不同，与背景反差程度不同。GMS 染色基底膜呈深棕色而与黄棕色背景反差较小；Gomori 染色基底膜显黑色与背景区分较明显，但有较多银颗粒沉积而影响观察；PAS 染色基底膜呈紫红色，基底膜形态清晰可见，背景浅，反差明显。结论：三种染色均可良好地显示角结膜原位癌基底膜，其中 PAS 染色显色更为鲜明、与背景反差更明显、操作更为方便，是一种理想的基底膜染色方法。

Objective: To compare the advantages and disadvantages of Periodic Acid-Schiff (PAS), Grocott Methenamine silver (GMS) and Gomori special staining methods in displaying the basement membranes in corneal and conjunctival carcinoma in situ, and to find the more suitable staining method. Methods: Twenty samples of corneal and conjunctival carcinoma in situ in the Clinical Pathology Department of Zhongshan Ophthalmic Center, Sun Yat-sen University from January 2012 to September 2017 were stained with three special staining methods of PAS, GMS and Gomori. We observed the staining results of basement membranes under microscope in cornea and conjunctiva carcinoma in situ. Results: The basement membranes in cornea and conjunctiva carcinoma in situ could be showed in all the three special staining methods. They were dark brown in GMS staining with yellow-brown background. They were black in Gomori staining with deposited silver particles in the background. The basement membranes were bright purple in PAS staining with light purple background and good contrast to background. Conclusion: PAS is an ideal method in showing basement membranes in corneal and conjunctival carcinoma in situ with bright color and strong contrast to background in these three special staining methods.