目的：该课题通过对纳入患者进行术前艾森克人格问卷调查及性别、年龄、文化程度、收入水平等 资料收集，与白内障术后1天、1月、3月的视觉满意度进行Logistic有序回归分析术后视觉满意度与人格特质等因素的关联性，以期以期探究患者植入非球面型人工晶体后视觉满意度与人格特质的关联，同时也可根据艾森克人格问卷评分对患者的预后视觉满意度进行必要术前告知沟通，降低术后预期值，提高视觉满意度，减少纠纷。方法：按照纳入标准筛选出年龄在40~84岁的112名患者，其中男性65例，女性47例。术前记录性别、年龄、收入水平及文化程度及森克人格问卷简式量表中国版(Eysenck Personality Questionnaire Revise Short Scale，EPQ-RSC)调查结果。由经验丰富的同一术者进行手术，随访并记录术后1天、1月、3月的视觉满意度。对视觉满意度进行描述性统计分析，并以不同人格特质(E、P、N、L量表所得T分)、年龄、性别、文化程度、收入水平作自变量，以视觉满意度(术后1天、1月、3月)作因变量用SPSS19做logistic有序回归分析。并将有统计学关联的因子不同组别 的视觉满意度行Kruskal Wallis分析(H检验)看组间是否存在统计学差异，若存在，再进行两两秩和检验予以比较。结果：术后1天、1月、3月总视觉满意度分别为90.18%、82.41%、90.18%。Logistic回归分析得出：术后1天，男性患者，属中间型E类人格的患者视觉满意度较高。术后1月，年龄在40~49岁， 属中间型E类人格，患者视觉满意度较高。术后3月，年龄在40~49岁，属中间型E类人格，患者视觉满意度较高。相关因素行H检验后只有E量表的P<0.05，存在统计学意义，对E组内的不同分组行两两 秩和检验后得出多组间存在统计学差异，典型外向型E类人格视觉满意度最高，中间型视觉满意度次之，倾向内、外向型E类人格视觉满意度均偏低，且倾向内向型视觉满意度最低。结论：白内障患者超声乳化术后1天、1月、3月的总体视觉满意度间存显著差异，术后1天视觉满意度较高，术后1月略有下降，而术后3月视觉满意度提高。术后3月不同E量表表型的视觉满意度间存在统计学差异。

目的：该课题通过对纳入患者进行术前艾森克人格问卷调查及性别、年龄、文化程度、收入水平等 资料收集，与白内障术后1天、1月、3月的视觉满意度进行Logistic有序回归分析术后视觉满意度与人格特质等因素的关联性，以期以期探究患者植入非球面型人工晶体后视觉满意度与人格特质的关联，同时也可根据艾森克人格问卷评分对患者的预后视觉满意度进行必要术前告知沟通，降低术后预期值，提高视觉满意度，减少纠纷。方法：按照纳入标准筛选出年龄在40~84岁的112名患者，其中男性65例，女性47例。术前记录性别、年龄、收入水平及文化程度及森克人格问卷简式量表中国版(Eysenck Personality Questionnaire Revise Short Scale，EPQ-RSC)调查结果。由经验丰富的同一术者进行手术，随访并记录术后1天、1月、3月的视觉满意度。对视觉满意度进行描述性统计分析，并以不同人格特质(E、P、N、L量表所得T分)、年龄、性别、文化程度、收入水平作自变量，以视觉满意度(术后1天、1月、3月)作因变量用SPSS19做logistic有序回归分析。并将有统计学关联的因子不同组别 的视觉满意度行Kruskal Wallis分析(H检验)看组间是否存在统计学差异，若存在，再进行两两秩和检验予以比较。结果：术后1天、1月、3月总视觉满意度分别为90.18%、82.41%、90.18%。Logistic回归分析得出：术后1天，男性患者，属中间型E类人格的患者视觉满意度较高。术后1月，年龄在40~49岁， 属中间型E类人格，患者视觉满意度较高。术后3月，年龄在40~49岁，属中间型E类人格，患者视觉满意度较高。相关因素行H检验后只有E量表的P<0.05，存在统计学意义，对E组内的不同分组行两两 秩和检验后得出多组间存在统计学差异，典型外向型E类人格视觉满意度最高，中间型视觉满意度次之，倾向内、外向型E类人格视觉满意度均偏低，且倾向内向型视觉满意度最低。结论：白内障患者超声乳化术后1天、1月、3月的总体视觉满意度间存显著差异，术后1天视觉满意度较高，术后1月略有下降，而术后3月视觉满意度提高。术后3月不同E量表表型的视觉满意度间存在统计学差异。

Purpose: To report target z-axis optimized LASIK treating for two eyes from two patients with decentered ablation.

Methods: The LaserSight AstraPro2.2Z software is a topography-guided custom ellipsoid ablation platform. LASIK with target z-axis optimization was performed to restore pre-operative visual axis using a LaserSight 1.0 excimer laser (version 5.3, 300Hz).

Results: During pre-operative examination, the uncorrected visual acuity (UCVA) was 0.5 in both eyes, and the best spectacle-corrected visual acuity (BSCVA) was 1.0 and 0.8. The decentered ablation zones were diagnosed with LaserSight AstraMax topography. Following target z-axis micro-translation, fifteen and eight microns of central corneal tissues were preserved in the two eyes respectively. The UCVA was 1.2 in both eyes, and secondary ablation zones were both centered on the visual axis. Topography maps and UCVA were stable in both eyes at the time of final follow-up.

Conclusions: Using target Z-axis optimized LASIK with the LaserSight AstraPro Planner 2.2 Z customized ablation software was an effective method to modify decentered ablation and restore the visual axis.

Purpose: To report target z-axis optimized LASIK treating for two eyes from two patients with decentered ablation.

Methods: The LaserSight AstraPro2.2Z software is a topography-guided custom ellipsoid ablation platform. LASIK with target z-axis optimization was performed to restore pre-operative visual axis using a LaserSight 1.0 excimer laser (version 5.3, 300Hz).

Results: During pre-operative examination, the uncorrected visual acuity (UCVA) was 0.5 in both eyes, and the best spectacle-corrected visual acuity (BSCVA) was 1.0 and 0.8. The decentered ablation zones were diagnosed with LaserSight AstraMax topography. Following target z-axis micro-translation, fifteen and eight microns of central corneal tissues were preserved in the two eyes respectively. The UCVA was 1.2 in both eyes, and secondary ablation zones were both centered on the visual axis. Topography maps and UCVA were stable in both eyes at the time of final follow-up.

Conclusions: Using target Z-axis optimized LASIK with the LaserSight AstraPro Planner 2.2 Z customized ablation software was an effective method to modify decentered ablation and restore the visual axis.

目的：观察青光眼引流钉植入术治疗难治性青光眼的疗效。方法：对联合应用抗青光眼药物无法控制的难治性开角型青光眼19例19只眼行青光眼引流钉植入术，术中应用丝裂霉素(2 mg /6~8 mL，2.5~4 min)及可松解缝线。术后1天、2周和1、3、6、12个月进行随访，观察眼压、视力、滤过泡形态、前房深度、眼底C/D、降眼压药物使用情况、完全及部分成功率 及有无并发症等情况。结果：19例患者中，术后完全成功率78.9%(15例)，部分成功率10.5% (2例)，失败10.5%(2例)。术前用3~5种降眼压药，眼压控制于27.7±10.1 mmHg。术后随访仅三人需使用1~2种降压药物。眼压下降组间有显著性意义(P<0.001)。与术前相比，术后1天(11.8±7.7 mmHg，P<0.001)，术后2周(10.1±4.2 mmHg，P<0.05)，1个月(12.0±4.0 mmHg，P=0.001)，6个月(12.2±3.4 mmHg，P<0.001)，1年(13.1±3.3 mmHg，P=0.001)及2年随访(14.5±2.5 mmHg，P=0.001)，眼压下降均具有显著性意义。术后患者视力、前房深度及C/D改变差异无显著性意 义。末次随访滤过泡弥散隆起57.9%(11例)，微囊型15.8%(3例)，瘢痕型21.1%(4例)，包裹型5.3%(1例)。所有患者均未观察到明显的术后并发症的发生。结论：房水引流钉植入术治疗难治性开角型青光眼手术成功率高，并发症少，值得推广。

目的：观察青光眼引流钉植入术治疗难治性青光眼的疗效。方法：对联合应用抗青光眼药物无法控制的难治性开角型青光眼19例19只眼行青光眼引流钉植入术，术中应用丝裂霉素(2 mg /6~8 mL，2.5~4 min)及可松解缝线。术后1天、2周和1、3、6、12个月进行随访，观察眼压、视力、滤过泡形态、前房深度、眼底C/D、降眼压药物使用情况、完全及部分成功率 及有无并发症等情况。结果：19例患者中，术后完全成功率78.9%(15例)，部分成功率10.5% (2例)，失败10.5%(2例)。术前用3~5种降眼压药，眼压控制于27.7±10.1 mmHg。术后随访仅三人需使用1~2种降压药物。眼压下降组间有显著性意义(P<0.001)。与术前相比，术后1天(11.8±7.7 mmHg，P<0.001)，术后2周(10.1±4.2 mmHg，P<0.05)，1个月(12.0±4.0 mmHg，P=0.001)，6个月(12.2±3.4 mmHg，P<0.001)，1年(13.1±3.3 mmHg，P=0.001)及2年随访(14.5±2.5 mmHg，P=0.001)，眼压下降均具有显著性意义。术后患者视力、前房深度及C/D改变差异无显著性意 义。末次随访滤过泡弥散隆起57.9%(11例)，微囊型15.8%(3例)，瘢痕型21.1%(4例)，包裹型5.3%(1例)。所有患者均未观察到明显的术后并发症的发生。结论：房水引流钉植入术治疗难治性开角型青光眼手术成功率高，并发症少，值得推广。

Purpose: To investigate the inhibitory effect of diclofenac sodium on rabbit corneal epithelial cells (RCECs) in vitro and explore its pharmacological mechanism.

Methods: The fresh rabbit cornea was cultured to get the primary RCECs, and RCECs of passage 2 were used for the research. The cells were divided into experimental groups, in which the cells were incubated with different concentrations (18.18, 27.27, 36.36, 45.45, 54.55 μg/ml) of diclofenac sodium, and a control group. The effect of diclofenac sodium on the proliferation of cells was measured by methyl thiazolyl tetrazolium (MTT) assay 24, 48, and 72 h after incubation. While the RCECs were divided into experimental groups, the cells in which were incubated with 9 and 12.5 μg / ml diclofenac sodium, and a control group. The cell cycle and apoptotic rate were observed by flow cytometer.

Results: MTT assay showed that diclofenac sodium had an obvious inhibitory effect on RCECs, and the inhibition rate was increasing along with the increase of the concentration of diclofenac sodium and the incubation time (P < 0.05). Flow cytometer showed that after incubation with diclofenac sodium, the cells in G₀/G₁ phase were obviously increased, and the apoptosis cusp and apoptotic rate were increased.

Conclusion: Diclofenac sodium has an obvious inhibitory effect on RCECs, which was dosage-dependent, and it may function by inducing cell apoptosis and ceasing cell cycles

Purpose: To investigate the inhibitory effect of diclofenac sodium on rabbit corneal epithelial cells (RCECs) in vitro and explore its pharmacological mechanism.

Methods: The fresh rabbit cornea was cultured to get the primary RCECs, and RCECs of passage 2 were used for the research. The cells were divided into experimental groups, in which the cells were incubated with different concentrations (18.18, 27.27, 36.36, 45.45, 54.55 μg/ml) of diclofenac sodium, and a control group. The effect of diclofenac sodium on the proliferation of cells was measured by methyl thiazolyl tetrazolium (MTT) assay 24, 48, and 72 h after incubation. While the RCECs were divided into experimental groups, the cells in which were incubated with 9 and 12.5 μg / ml diclofenac sodium, and a control group. The cell cycle and apoptotic rate were observed by flow cytometer.

Results: MTT assay showed that diclofenac sodium had an obvious inhibitory effect on RCECs, and the inhibition rate was increasing along with the increase of the concentration of diclofenac sodium and the incubation time (P < 0.05). Flow cytometer showed that after incubation with diclofenac sodium, the cells in G₀/G₁ phase were obviously increased, and the apoptosis cusp and apoptotic rate were increased.

Conclusion: Diclofenac sodium has an obvious inhibitory effect on RCECs, which was dosage-dependent, and it may function by inducing cell apoptosis and ceasing cell cycles

A 74-year-old man presented with a three-year history of foreign body sensation in the right eye after cataract surgery. He underwent uneventful trabeculectomy with mitomycin C (MMC) in the right eye seven years ago. Slit-lamp examination revealed a large avascular filltration bleb overhanging on the cornea with a thin base connected to the conjunctiva. Preoperative ultrasound biomicroscopy (UBM) impressions were confirmed by leakage of aqueous from the incision intraoperatively. Surgical dissection and revision of the bleb was performed with satisfactory outcome. Histopathologic evaluation showed proliferation of fibrous tissue under the conjunctival epithelia with irregular cystoids change. The current case may be the first report of a post-trabeculectomy overhanging filtration bleb related to cataract surgery. The possible mechanism may be related to microleakage of the surgical wound after phacoemulsiff cation which initiated the healing and scarring process.

A 74-year-old man presented with a three-year history of foreign body sensation in the right eye after cataract surgery. He underwent uneventful trabeculectomy with mitomycin C (MMC) in the right eye seven years ago. Slit-lamp examination revealed a large avascular filltration bleb overhanging on the cornea with a thin base connected to the conjunctiva. Preoperative ultrasound biomicroscopy (UBM) impressions were confirmed by leakage of aqueous from the incision intraoperatively. Surgical dissection and revision of the bleb was performed with satisfactory outcome. Histopathologic evaluation showed proliferation of fibrous tissue under the conjunctival epithelia with irregular cystoids change. The current case may be the first report of a post-trabeculectomy overhanging filtration bleb related to cataract surgery. The possible mechanism may be related to microleakage of the surgical wound after phacoemulsiff cation which initiated the healing and scarring process.

To report the case of a patient who presented with idiopathic choroidal neovascularization (CNV) as the first sign of multiple evanescent white dot syndrome (MEWDS). A 25-year-old woman presented with recent onset of decreased vision and metamorphopsia in the right eye. The results of fundoscopic examination, fluorescein angiography, and optical coherence tomography (OCT) were compatible with a diagnosis of idiopathic CNV, which was treated with one intravitreal injection of bevacizumab. Five years later, the patient returned complaining of photopsia and decreased vision in the same eye. The fundoscopic examination showed typical signs of MEWDS. After 3 months, recurrence of CNV was observed in the same eye. In conclusion, idiopathic CNV might be the only manifestation of a subclinical occurrence of MEWDS. In this case, it was followed by a recurrence of MEWDS and subsequent reactivation of CNV. 

To report the case of a patient who presented with idiopathic choroidal neovascularization (CNV) as the first sign of multiple evanescent white dot syndrome (MEWDS). A 25-year-old woman presented with recent onset of decreased vision and metamorphopsia in the right eye. The results of fundoscopic examination, fluorescein angiography, and optical coherence tomography (OCT) were compatible with a diagnosis of idiopathic CNV, which was treated with one intravitreal injection of bevacizumab. Five years later, the patient returned complaining of photopsia and decreased vision in the same eye. The fundoscopic examination showed typical signs of MEWDS. After 3 months, recurrence of CNV was observed in the same eye. In conclusion, idiopathic CNV might be the only manifestation of a subclinical occurrence of MEWDS. In this case, it was followed by a recurrence of MEWDS and subsequent reactivation of CNV. 

We report a case of large graphite foreign body (FB) in the anterior chamber of eye of a 4-yearold child, incurred during unsupervised play. Despite delayed presentation, the eye had few signs of resolved inff ammation which allowed safe extraction of the FB bimanually through limbus. School play, especially in young children, should be under supervision and free of sharp objects. Graphite is inert while inside the eye, and even large pieces can be well tolerated for long time in absence of infection.  

We report a case of large graphite foreign body (FB) in the anterior chamber of eye of a 4-yearold child, incurred during unsupervised play. Despite delayed presentation, the eye had few signs of resolved inff ammation which allowed safe extraction of the FB bimanually through limbus. School play, especially in young children, should be under supervision and free of sharp objects. Graphite is inert while inside the eye, and even large pieces can be well tolerated for long time in absence of infection.