目的：探讨白内障人群角膜屈光力(corneal refractive power,CRP)的分布特点及与眼生物学参数的相关因素分析。方法：回顾性横断面研究福州眼科医院2019年3月至2022年7月就诊的40岁以上白内障人群共23035眼，使用OA-2000测量其眼轴(axial length,AL)、CRP、前房深度(anterior chamber depth,ACD)、晶状体厚度(lens thickness,LT)、角膜水平直径即白到白(white-to-white,WTW)、中央角膜厚度(central corneal thickness,CCT)。绘制各眼生物学参数及年龄Spearman相关性热力图，绘制CRP与AL、CRP与WTW散点拟合图。将CRP与上述参数及年龄进行Spearman相关性分析，分段数据的线性关系使用Pearson分析及线性回归分析。结果：白内障人群CRP为(44.36±1.52)D，在总体数据中CRP与AL为非线性相关；但在分段数据中存在线性相关：当AL≤25.06 mm，CRP与AL负线性相关(R² =0.397，P<0.001)；当AL>25.06 mm，CRP与AL正线性相关(R² =0.045，P<0.001)；无论AL长短，CRP与WTW、CCT均呈负相关。在总体数据中，CRP与WTW也存在非线性关系；但在分段数据中存在线性相关：当10.52 mm≤WTW≤12.46 mm，CRP与WTW负线性相关(R² =0.149，P<0.001)，并与AL、ACD、CCT呈负相关。结论：CRP与AL、WTW呈非线性相关，使用CRP优化计算人工晶状体(intraocular lens,IOL)屈光力时需适当考虑AL、WTW与CRP的相关性。

Objective: To investigate the distribution characteristics of corneal refractive power (CRP), and analyze the correlation between corneal refractive power and ocular biometric parameters in cataract patients. Methods: A retrospective cross-sectional study was conducted on 2,3035 eyes of cataract patients over 40 years old, who visited Fuzhou Eye Hospital during the period between March 2019 and July 2022. The subjects' examination results of axial length (AL), corneal refractive power (CRP), anterior chamber depth (ACD), lens thickness (LT), horizontal corneal diameter (WTW), central corneal thickness (CCT) were measured by OA-2000. Spearman correlation thermograms of bilological parameters and age for each eyes were worked out. The plot scatter fitting plots of CRP and AL, CRP and WTW were made. Spearman correlation analysis was made among CRP, above-mentioned parameters and age. Linear relationships of the segmented data were analyzed with Pearson and linear regression analysis. Results: In the cataract patients, CRP was (44.36 ± 1.52) D. There was a non-linear correlation between CRP and AL in the total data. However, there was a linear relationship in the segmented data. When AL ≤ 25.06 mm, CRP was negatively linearly correlated with AL (R² =0.397, P<0.001). When AL>25.06 mm, CRP was weakly positively correlated with AL (R² =0.045, P<0.001). Regardless of the length of AL, CRP was negatively correlated with WTW and CCT. There was also a nonlinear relationship between CRP and WTW in the total data. But there was a linear correlation in the segmented data.When 10.52 mm ≤ WTW ≤ 12.46 mm, the negative linear correlation was found between CRP and WTW (R² =0.149, P<0.001), while there was negative correlation among CRP, AL, ACD, and CCT. Conclusion: There is a non-linear correlation among CRP, AL and WTW. To optimize the calculation of intraocular lens (IOL) refractive power with CRP, it is necessary to consider the correlation between AL, WTW, and CRP.

该文报道了一例40岁女性患者，因“双眼渐进性视物模糊3个月”就诊。患者既往于2005年因高度近视行双眼准分子激光原位角膜磨镶术 (LASIK)。最佳矫正视力OD：0.2 (–11.00 DS/ –1.25 DC×170 °)，OS：0.7 (–4.00 DS/ –0.75 DC×25 °)。双眼角膜透明，前房中深，晶状体混浊，豹纹状眼底伴后巩膜葡萄肿。诊断为双眼并发性白内障，并行右眼白内障超声乳化联合人工晶状体 (IOL) 植入术，术中植入+14.0 D IOL一枚，目标屈光度为–0.5 D。术后1周裸眼视力0.3，验光结果示右眼屈光度+2.75 DS，最佳矫正视力0.7。术后2周行右眼IOL置换术，由+14.0 D置换为+17.0 D。右眼术后1周裸眼视力0.8，验光结果示右眼屈光度–0.75 DC×15 °。

It is reported in this article that a 40-year-old female patient presented with "progressive blurred vision of both eyes for 3 months". The patient underwent bilateral laser in situ keratomileusis (LASIK) because of high myopia in 2005. It was recorded that her best corrected visual acuity was 0.2 (–11.00 DS/ –1.25 DC×170 °) in the right eye and 0.7 (–4.00 DS/ –0.75 DC×25 °) in the left, and clear cornea, normal anterior chamber, cloudy lens, tessellated fundus with posterior staphyloma in both eyes. The patient was diagnosed with bilateral complicated cataract. Phacoemulsification combined with intraocular lens (IOL, +14.0 diopter (D)) implantation was performed on the right eye, with the target –0.5D refractive diopter . One week after surgery, it was recorded that the uncorrected visual acuity of the right eye was 0.3, and the best corrected visual acuity was 0.7 (+2.75 DS). IOL replacement of the right eye was performed two weeks after surgery, the +14.0 D IOL was replaced by +17.0 D IOL. One week after surgery, the uncorrected visual acuity of the right eye was 0.8 (–0.75 DC×15 °).

准分子激光原位角膜磨镶术(laser-assisted in situ keratomileusis,LASIK)是矫正屈光不正的重要角膜屈光手术方式之一。经过准分子激光切削的角膜，生物测量数据发生改变。对于此类患者，通过常规测量获得的参数数据以及使用常规计算公式确定的IOL屈光度将变得不再准确，由此将会导致术后较大的屈光误差，进而影响患者的视觉质量。本文报道一例46岁的男性白内障患者。该患者既往双眼屈光不正，曾接受过LASIK手术治疗。白内障术前角膜地形图检查发现该患者双眼存在角膜偏心切削，这为IOL屈光度的确定带来困难。手术医生通过角膜地形图判断角膜切削的居中性，在特定区域内选择角膜曲率K值，并采用Barrett True K公式计算出IOL屈光度。白内障术后患眼屈光误差相对较小，视力提高，视觉质量改善。

Laser-assisted in situ keratomileusis (LASIK) is a crucial corneal refractive surgery for correcting refractive errors. The cornea, after undergoing excimer laser ablation, undergoes changes in biometric measurements. For such patients, conventional measurements and IOL power calculations based on standard formulas may no longer be accurate, leading  to significant postoperative refractive errors and subsequently impacting the patient's visual quality. This article presents a case of a 46-year-old male cataract patient who had a history of refractive errors in both eyes and had previously undergone LASIK surgery. Preoperative corneal topography revealed corneal eccentric ablation in both eyes, posing challenges in determining IOL power. The surgeon assessed the centration of corneal ablation using corneal topography, selected the keratometry value (K value) within specific corneal regions, and calculated the IOL power using the Barrett True K formula. Postoperatively, the cataract patient experienced relatively minor refractive errors, leading to improved vision and enhanced visual quality.

近年来，眼部电流刺激(electrical stimulation,ES)在不同方向的研究中逐渐揭示了其在多种视网膜疾病中的潜在治疗价值。其中，经角膜电刺激(transcorneal electrical stimulation,TES)作为一种非侵入性的治疗方法，能对视网膜、视神经、眼底血管及其相关结构产生积极的影响。TES能够改善视力，在保护感光细胞和减缓疾病进展方面显示出积极效果，提高患者的生存质量，还能够在不损伤眼球的情况下调节大脑中的神经元活动，为视网膜疾病的治疗提供一种新的选择。该文对近年来TES在视网膜色素变性(retinitis pigmentosa,RP)、年龄相关性黄斑变性(age-related macular degeneration,AMD)、视网膜血管病、青光眼以及视神经病变等疾病中的应用研究进行了综述。研究发现，TES治疗是一种安全且无需手术的辅助治疗工具，具有广泛的应用前景。该文旨在为临床医师提供一个全面的TES研究概述，并深入探讨其在眼科学领域的潜在应用价值。然而，TES治疗的具体机制仍需进一步探讨，以便更好地应用于临床实践。同时，未来研究还应关注TES与其他治疗方法相结合的效果，以期为患者提供更多有效的治疗选择。

In recent years, electrical stimulation of the eye (ES) has gradually revealed its potential therapeutic value in a variety of retinal diseasesin different directions. Among them, transcorneal electrical stimulation (TES), as a non-invasive treatment, can have a positive effect on the retina, optic nerve, fundus vessels and related structures. TES can improve vision, show positive effects in protecting photoreceptor cells and slowing disease progression, improve the quality of life of patients, and can regulate neuronal activity in the brain without damaging the eyeball, providing a new option for the treatment of retinal diseases. The research on the application on TES on retinitis pigementosa (RP), age-related macular degeneration (AMD), retinal angiopathy, glaucoma and optic neuropathy are reviewed in this article. It is found in the study that TES therapy is a safe and surgery-free adjuvant therapy tool, and has a wide application prospect. The purpose of this article is to provide clinicians with a comprehensive overview of TES research,and to explore its potential application value in the field of ophthalmology. However, the specific mechanism of TES therapy still needs to be further explored in order to better apply in clinical practice. At the same time, future studies should also focus on the effect of combining TES with other treatment methods, in order to provide more effective treatment options for patients.

目的：探讨胬肉切除联合自体角膜缘干细胞移植治疗翼状胬肉的远期效果。

方法：2003年12月－2008年12月在我院就诊的原发性翼状胬肉患者55例57眼，均采用胬肉切除联合自体角膜缘干细胞移植治疗，术后随访2～8年，平均5.3年。观察创面愈合情况、治疗效果和并发症情况。

结果：术后早期患者均有不同程度的充血、水肿和异物感，3～5d 后症状逐渐减轻，一周左右完全消失。角膜创面完全上皮化时间为4～7d，平均4.83d。术后有持续性眼表刺激症状者7例，术后残留纤维组织者1例，角膜浅层瘢痕者4例。术后随访2～8年，平均5.3年，复发8例8眼 (复发率13.11％)。术后1年时复查OSDI 评分，所有患者较术前评分均有不同程度的降低，与术前相比，两组评分和构成比差异有统计学意义(P＜0.05)。术后5年时复查OSDI评分较1年前稍有降低，但差异没有统计学意义(P＞0.05)。术后1、5年时泪液基础分泌[(12.95±4.03) mm，(12.68±4.77) mm]和泪膜破裂时间 [(10.55±4.13)s, (10.03±4.64) s] 较术前[(9.48±3.34)mm，(8.14±3.57)s] 明显改善，差异有统计学意义(P＜0.05)。

结论：应用胬肉切除联合自体角膜缘干细胞移植治疗翼状胬肉，术后早期症状轻、消失快，远期复发少，效果良好。

Purpose: To evaluate the long-term efficacy of pterygium excision combined with autologous corneal limbal stem cell transplantation in the treatment of pterygium．

Methods: Fifty five patients (57 eyes) diagnosed with primary pterygium undergoing pterygium excision combined with autologous corneal limbal stem cell transplantation between December 2003 and December 2008 were enrolled in this study. Postoperative follow-up endured for 2-8 years, 5.3 years on average. The wound healing, clinical efficacy and postoperative complications were observed．

Results: During early stage after surgery, all patients presented with varying degree of hyperemia, edema and sense of foreign body, which were gradually mitigated 3-5 d later and completely recovered in approximately 1 week. The corneal wound was completely epithelized within 4-7 d, 4.83 d on average. Seven patients had persistent ocular surface irritation symptoms after surgery, one case had residual fibrous tissues and four patients developed superficial corneal scars. Postoperative follow-up endured for 2-8 years, 5.3 years on average. Eight patients (8 eyes) recurred with a recurrence rate of 13.11％. In all patients,  postoperative OSDI score was significantly decreased at 1-year reexamination. OSDI score and constitution ratio significantly differed between two groups (both P＜0.05)．At postoperative 5 years, OSDI score was slightly lower compared with that in last year with no statistical significance(P＞0.05)．At post operative 1- and 5-year, basic tear secretion was (12.95 ±4.03) mm and (12.68 ±4.77) mm, tear film break-up time was (10.55±4.13)s and (10.03±4.64)s. Both indexes were significantly improved compared with (9.48±3.34) mm and (8.14±3.57)s before surgery (all P＜0.05)．

Conclusion: Pterygium excision combined with autologous corneal limbal stem cell transplantation is an efficacious treatment of pterygium with mild postoperative symptoms, rapid recovery, low long-term recurrence rate and high efficacy． 

目的：探讨非超声乳化白内障手术两种不同的娩核方式对角膜内皮细胞数量和形态的影响，以及对术后视力恢复情况的影响。

方法：选择在本院手术治疗的40例白内障患者娩核方式分为直接娩出组和半娩出组，并根据 Emery－ little晶状体核硬度分级标准分为软核和硬核，手术方式为白内障非超声乳化手术，术后第3天用角膜内皮镜检查并记录角膜内皮细胞数量和形态。术后随访3个月，比较并观察4组患者术前和术后角膜内皮细胞丢失率、形态变化和视力恢复情况。

结果：术前和术后3个月角膜内皮细胞丢失率比较，硬核直接娩出组与另外三组比较差异有统计学意义(P＜0.01)，而软核直接娩出组、硬核半娩出组与软核半娩出组比较差异无统计学意义(P＞0.05)。术前和术后第二天视力比较硬核半娩出组和软核直接娩出组之间无统计学意义(P＝0.49)，软核半娩出组与这两组比较有统计学意义(P＝0.030)，硬核直接娩出组与这两组之间比较也有统计学意义(P＝0.14)，术后三个月视力比较4组之间均无统计学意义(P＝0.067)。术后 3 个月角膜内皮细胞形态变化不明显。

结论：白内障非超声乳化手术时，硬核直接娩核法对角膜内皮细胞损伤最大，软核半娩核法对角膜内皮损伤最小。若内皮细胞损伤较轻，对手术3个月后视力和角膜内皮细胞形态无明显影响。 

Purpose: To investigate the effect of non-phacoemulsification cataract operation in two different patterns of nucleus delivery on the quantity and morphology of corneal endothelial cells and postoperative visual acuity．

Methods: Forty patients diagnosed with cataract underwent cataract surgery and were assigned into the direct nuclear delivery and semi-nuclear delivery groups. Lens density was measured and divided into the hard and soft lenses according to Emery-little lens nucleus grading system. Non-phacoemulsification cataract operation was performed. At 3 d after surgery, the quantity and morphology of corneal endothelium were counted and observed under corneal endothelial microscope. During 3-month postoperative follow-up, the endothelial cell loss rate, morphological changes and visual acuity were compared among four groups．

Results: Corneal endothelial cell loss rate in the direct delivery of hard nucleus group significantly differed from those in the other three groups before and 3 months after operation (P＜0.01),  whereas no statistical significance was found among the direct delivery of soft nucleus,  semi-delivery of hard nucleus and semi-delivery soft nucleus groups (all P＞0.05).  Preoperative and postoperative 2-d visual acuity did not differ between the semi-delivery of hard nucleus and direct delivery of soft nucleus groups (P＝0.49)，significantly differed from those in the semi-delivery of soft nucleus (P＝0.03) and direct delivery of hard nucleus groups (P＝0.14). Visual acuity at postoperative four months did not differ among four groups (P＝0.067). 
Conclusion: During non-phacoemulsification cataract surgery, direct delivery of hard nucleus caused severe injury to corneal endothelium and semi-delivery of soft nucleus yielded mild corneal endothelial injury. Slight corneal endothelial injury exerted no apparent effect upon visual acuity and corneal endothelial morphology at three months after surgery．

目的：总结了日间病房收治 8 例板层角膜移植手术的管理及其效果。

方法：回顾分析8例日间病房模式下行角膜移植手术患者的工作流程和病历资料。

结果：8例患者术后恢复理想，其中1例真菌性角膜溃疡的患者术后2个月感染复发行常规住院治疗。

结论：板层角膜移植日间病房模式的管理重点包括详细制定并不断完善工作流程，对患者入选条件、术前后护理、出院后随访这些关键环节进行质控，并简化护理文书、加强心理护理和医护合作，提高工作效率。

Purpose：The management and efficacy of lamellar keratoplasty of 8 patients in day-care unit were summarized．

Methods：The work flow and medical record of 8 cases undergoing corneal transplantation in day-care unit were retrospectively analyzed．

Results：Eight patients were fully recovered．One case with fungal keratohelcosis was re-infected at postoperative 2 months and hospitalized．

Conclusion：During lamellar keratoplasty in day-care unit, the work flow should be explicitly established and modified. The quality of patient selection, preoperative and postoperative nursing, follow-up after discharge should be carefully assured．In addition, nursing paperwork should be simplified, psychological nursing should be strengthened, and doctors and nurses should cooperate closely to enhance work efficiency． 

目的：总结了角膜胶原交联术治疗圆锥角膜的护理及其效果。

方法：回顾分析30例（31眼）角膜胶原交联术患者术前术后护理记录及病历资料。

结果：30 例（31眼）患者病情得到控制，术后恢复理想，术后一个月复查视力都有提高。

结论：角膜胶原交联术护理重点在于术前协助患者完善各项检查、相关健康知识宣教及有效的心理护理，术后严密观察病情变化、减轻病人痛苦、预防感染及促进角膜上皮修复治疗。

Purpose：To summarize the nursing experience and clinical efficacy of corneal collagen cross-linking in treating keratoconus．

Methods：Preoperative and postoperative nursing and medical record of 30 patients (31 eyes) undergoing corneal collagen cross-linking were retrospectively analyzed．

Results：The the severity of diseases in all 30 patients (31 eyes) was properly controlled．All cases were fully recovered．The visual acuity at postoperative one month was improved in all cases．

Conclusion：assistance in terms of preoperative examination，education of health knowledge and effective psychological nursing play a pivatol role in the nursing before and after corneal collagen cross-linking．Following surgery，postoperative changes in the the severity of diseases should be strictly observed. Much attention should be diverted to ease patients' pain，prevent infection and accelerate the healing of corneal epithelium． 

目的：规范感染性角膜炎的隔离管理。方法：回顾性分析感染性角膜炎患者在住院期间发生交叉感染的危险因素，探讨现行的隔离管理措施是否有效。结果：隔离管理到位，5年的院感发生率为0.08%。结论：规范感染性角膜炎的隔离管理，能有效地预防医院感染。

Objective: To standardized the isolation and management of infectious keratitis. Methods: Risk factors of cross-infection of patients with infectious keratitis during their hospitalization were retrospectively reviewed to investigate whether the current isolation management is effective. Results: The current isolation management is effective since the incidence of hospital infection was 0.08% in past 5 years. Conclusion: Standardized the isolation management of infectious keratitis can prevent hospital infection efficaciously. 

目的：了解表面切削手术前后角膜透明性变化，初步建立角膜光密度与角膜上皮下雾状混浊(Haze)对应的数据库。方法：收集我院行表面切削手术的病人74人146眼。患者手术前、术后3个月行裂隙灯角膜透明性检查和眼前节分析仪(Pentacam，0表示角膜完全透光，100表示角膜混浊不透光)测量角膜光密度。使用SPSS13.0软件对数据进行统计，术前、术后3个月角膜光密度进行Wilcoxon秩和检验；根据裂隙灯下角膜透明性将术后数据分成透明角膜组和Haze组与术前分别对比。术后角膜光密度与裂隙灯下Haze分级进行等级资料Spearman相关分析；按照裂隙灯分级将不同程度Haze与角膜光密度对应，初步建立术后Haze的角膜光密度数据库。结果：术后3个月时，透明角膜(0级Haze)80眼、I级Haze49眼、II级Haze 13眼、III级Haze2 眼、IV级Haze2眼。术前最大 角膜光密度平均值为19.7±2.47，术后3个月时最大角膜光密度平均值为30.3±7.2，术后角膜光密度比术前升高(Z=?7.404，P<0.001)；另外术后Haze组和术后透明角膜组光密度分别为38.2±15.2和21.2±3.51，与术前比两者差异也有统计学意义(Z=?4.783，P<0.001；Z=?5.195，P<0.001)。术后角膜光密度与Haze呈正相关(r=0.819，P<0.001)。各级Haze组对应角膜光密度参考值为I级Haze：29.4±2.58；II级Haze 43.2±5.68；III级Haze：59.5±0.92；IV级Haze: 89.5±14.9。结论：Haze的出现使光密度增加，影响角膜的透明性。手术后裂隙灯观察下的透明角膜光密度较术前高，可能与术后角膜的炎症反应或胶原纤维排列变化有关，需要进一步研究明确。表面切削手术前后角膜的透明性除了传统的裂隙灯检查外，也可以用角膜光密度来评价。用角膜光密度来评价角膜的透明性比单纯的裂隙灯检查更容易发现细微的异常。

Objective: To measure corneal transparency before and after the surface ablation and establish a preliminary database of corneal density and haze. Methods: Seventy-four patients (146 eyes) who underwent surface ablation were measured with the slit lamp and the densitometry program of the Pentacam Scheimpflug imaging system (0=no clouding, 100=tissue completely opaque). The corneal density before and after operation were analyzed with the Wilcoxon’s Matched Pairs Test of the SPSS 13.0. Eyes of 3 months after operation were categorized as postoperative clear corneas and postoperative with haze. According to the slit lamp, different degrees of haze were correlated with corneal density to establish a preliminary corneal density database.Results: At 3 months after operation, there were 80 eyes with clear cornea (grade 0 haze) and 66 eyes with haze which contained 49 eyes with grade I haze, 13 eyes with grade II haze, 2 eyes with grade III haze and 2 eyes with grade IV haze. Maximum density of preoperative corneas was 19.7±2.47, and it was increased to 30.3±7.2 postoperation (Z=?7.404, P<0.001). Maximum density of postoperative clear corneal (21.2±3.51) and postoperative with haze (38.2±15.2) were both higher than preoperation (Z=?5.195, P=0.004 and Z=?4.783, P<0.001). And the haze correlated corneal density was grade I haze 29.4±2.58; grade II Haze 43.2±5.68; grade III haze 59.5±0.92; grade IV haze 89.5±14.9. Conclusion: Corneal density will increase with haze. Maximum density of postoperative clear corneal was higher than preoperation which may be influenced by the postoperative corneal inflammation or the rearrange of collagen ,and it need the further research. Besides the slit lamp, we can use the corneal density to measure the corneal transparency after surface ablation. The densitometry program of the Pentacam can provide a useful objective measure of postoperative and other mild corneal haze.