Patients with neuropathic corneal pain (NCP) have local and physical symptoms, but the clinical signs are atypical,and the treatment is not effect. With the improvement of standardization of diagnosis and treatment of dry eye, the number of patients with NCP has been increasing. The NCP is intertwined with systemic chronic pain syndrome.Corneal confocal microscope and in vivo blot cytology can find the signs of morphology and associated proteins variation. The treatments of NCP should be based on the principle of individualized, multidisciplinary treatment (MDT). This article reviews recent advances in the etiology, pathogenesis, and comprehensive treatment of NCP to guide clinical translational medicine research.

Objective: To explore the effect of quality control circle on improving the prone position execution rate of patients after vitrectomy. Methods: Establish quality control circle activity group, select improving the prone position execution rate of patients after vitrectomy as the activity theme, use quality control circle tools and methods to analyze the status quo, find out the influencing factors, formulate corresponding measures and implement them, and compare the prone position execution rate of patients before and after quality control circle activity. Results: The prone position execution rate of patients after vitrectomy increased from 64.70% to 95.83%.Conclusion: The application of quality control circle can significantly improve the prone position implementation rate of patients after vitrectomy, which is worthy of clinical promotion.

Objective: To analyze the incidence and causes of endophthalmitis after intravitreal injection and to further improve the safety of the surgery. Methods: The follow-up data of 973 eyes of 421 patients who received intravitreal injection in our hospital in the past 9 years at 1 day, 1 week and 1 month were retrospectively analyzed.The types of injected drugs, the cause of injection and systemic history were summarized, and the occurrence and treatment of postoperative endophthalmitis were summarized. Results: The intravitreal injections were safe.However, the severe complication of endophthalmitis (0.41%) occurred occasionally. Among these 4 patients with endophthalmitis, 2 patients were intravitreal injected triamcinolone acetonide because of Irvine-Gass syndrome;1 patient accepted intravitreal injection by Ranibizumab because of central retinal vein occlusion; 1 patient accepted intravitreal injection by Ranibizumab because of central exudative chorioretinopathy. The incidence of endophthalmitis (1.99%) after intravitreal injection of triamcinolone acetonide was higher than that of anti-vascular endothelial growth factor (VEGF) agents (0.12%). Conclusion: The clinical operating guideline of intravitreal injection should be followed strictly. Furthermore, the elderly people with hypertension diagnosed of Irvine-Gass syndrome have a higher risk of endophthalmitis after intravitreal injection of triamcinolone acetonide than others and should be paid more important attention.

Objective: To explore the effect of scanning signal intensity on the peripapillary vessel density measured by optical coherence tomography angiography (OCTA). Methods: This study was a single-center cross-sectional study. All the participants received comprehensive examinations including height, weight, blood pressure,intraocular pressure, axial length, and OCTA scan of the optic disc. The effect of OCTA scanning signal intensity on the peripapillary vessel density was analyzed using the generalized estimation equation. Results: A total of 186 participants with 359 eyes were included in this study. The mean age of all the participants was (47.86±17.86)years old, and the average peripapillary vessel density was (17.75±1.99)mm^?1. In a univariate analysis,peripapillary vessel density was associated with the axial length (β=?0.5120, P<0.001) and the scanning signal intensity (β=1.0240, P<0.001). After adjusting for age, gender, axial length, and optic disc area in the multivariate analysis, the OCTA scanning signal intensity was still significantly associated with the peripapillary vessel density (β=0.9721, P<0.001). Conclusion: The peripapillary vessel density is significantly negatively associated with the axial length and optic disc area, significantly positively associated with the scanning signal intensity. In clinical practice, the influence needs to be considered.

Cortical blindness(cortical blindness, CB) is very rare, which is an important cause of blindness due to bilateral lesions of the striate cortex in the occipital lobes caused by various reasons. The most common cause of cortical blindness is cerebrovascular disease, in which there are more cerebral infarction and very few are cerebral hemorrhage. In this case, a 74-year-old woman with CB caused by cerebral hemorrhage was first diagnosed in the Department of Ophthalmology. The main manifestations were acute binocular blindness and headache.There was no obvious abnormality in fundus, pupil and eyeball movement. The patient's head computed tomography showed right parietal-occipital cerebral hemorrhage with hematoma formation, a little hemorrhage in bilateral ventricles and subarachnoid hemorrhage. There was no significant change in ocular symptoms after dehydration and intracranial pressure reduction for 1 month. CB is rare and easy to be misdiagnosed and missed. Its diagnosis depends on the signs of neurology and imaging examination. CB have a worse prognosis and even leads to irreversible blindness. With improving the understanding of the disease and focusing on treating the etiology, vision improvements can be obtained in these patients. Hence early detection, early diagnosis and prompt treatment are the key to improve the quality of life of patients, which is of great clinical significance.

Objective: To observe and analyze the disease related factors of different types of macular hole. Methods: Clinical data including age, sex, ethnicity, best corrected visual acuity, macular hole type and whether accompanied by rhegmatogenous retinal detachment were retrospectively analyzed in 1 150 patients (1 202 eyes) hospitalized in our hospital from January 2012 to December 2018. Results: The number of patients with macular hole increased with age. There was statistically significant difference between male and female patients (P<0.05), and no statistically significant difference between eyes (P>0.05). The rate of rhegmatogenous retinal detachment caused by idiopathic macular hole was significantly lower than other types. The optimal corrected visual acuity of idiopathic macular hole was higher in admission, which was statistically different from that of high myopia macular hole and ametropia macular hole (P<0.05). Conclusion: Macular hole is more common in the elderly and more common in women. High myopia and ametropia macular hole are easily associated with rhegmatogenous retinal detachment, so surgical treatment should be arranged as soon as possible. Traumatic macular hole often occurs in young and middle-aged men and is often seen in blunt contusion of the eyeball. Each case of macular hole may have its particularity, which requires careful analysis of the condition, comprehensive analysis, and appropriate choice of observation or surgery.

Objective To construct nursing quality sensitive indicators in ophthalmic day ward, so as to provide standardized basis for nursing quality monitoring and evaluation in ophthalmic day ward. Methods Based on the theory of “Donabedian three dimensional quality structure model”，through literature review and group discussion, the preliminary construction of sensitive indicators were designed. The Delphi method was used to revise the indicators and then the final nursing quality sensitive indicator in ophthalmic day ward was established. Results After two rounds of Delphi method, the opinion of the experts became consistent. Questionnaire collecting rates of the two rounds were both 100%, and cooperation index were 0.129 and 0.342 respectively (P＜0.01). The nursing quality sensitive indicator in ophthalmic day ward consisted of 2 structural indicators, 8 process indicators and 3 outcome indicators. Conclusion The nursing quality sensitive indicators in ophthalmic day ward is scientific, reliable and feasible and has strong specialty characteristics, which provide a good evaluation method for evaluation of nursing quality in ophthalmic day ward.

Objective: To find differentially expressed genes between retinoblastoma and normal retinal tissues by bioinformatics analysis, and to investigate their molecular function and interactions in the transcriptional level.Methods: The gene expression profile datasets GSE97508 and GSE110811, including 34 retinoblastoma (RB) tissues and 6 normal retinal tissues, were downloaded from gene expression omnibus (GEO). Differentially expressed genes (DEGs) between normal retinal tissues and RB tissues were identified by GEO2R tool and the Draw Venn Diagrams software. The gene ontology (GO) analysis, KEGG pathway and protein-protein interaction (PPI) were analyzed by STRING. Results: In two microarrays of retinoblastoma we found total 20 DEGs were identified, including 3 up-regulated and 17 down-regulated genes. The GO ontology annotation results showed that the enrichment functions of up-regulated genes were mainly in cell division, chromosome enrichment, nuclear division, and DNA conformation change. Down-regulated genes were mainly concentrated in light conduction,visual perception, photoreceptor cell repair, photoreceptor cell inner and outer segment, and regulation of rhodopsin mediated signaling pathway. The KEGG pathway showed that there was no significant signal pathway in which up-regulated genes up-regulated DEGs, and down-regulated genes were involved in the phototransduction signaling pathway, including four genes of CNGA1, CNGB1, RHO and SAG. PPI network suggested that these four genes were interlinked, and RHO was found to be the most closely connected core gene with other nodes.Conclusion: Bioinformatics can be used effectively to analyze RB microarray data to provide theoretical reference for further exploration of tumorigenesis mechanism and help search for potential drug therapeutic targets.

Opacification of intraocular lenses is a relatively rare complication of cataract surgery, most patients visit because of unexplained degenerated or blurred vision months or years after surgery.This article reports a 73-year-old female patient who was implanted with the same type of hydrophilic acrylate intraocular lens in both eyes during the same period, and the intraocular lens in her right eye was totally opacified 6 years after surgery, while the left one was still completely transparent.The clinical ocular symptoms, findings of anterior segment optical coherence tomography and ultrasound biomicroscopy of the two eyes were significantly different. The visual acuity of the eye with opacified lens recovered satisfactorily . This paper recorded in detail the relevant preoperative data, surgical treatment, and examination results of the explanted intraocular lens, and analyzed and discussed it for the reference of experts and peers, so as to provide reference for the diagnosis and treatment of patients of this type in the future.