目的：研究阿托品作用下豚鼠眼在不同单色光中的屈光发育情况。方法：24 只 2 周龄 3 色种豚鼠被随机分成 3 组，分别在蓝光（430 nm）、绿光（530 nm）和白光（色温 5000 k）中饲养。3 组豚鼠的双眼从实验开始点 1% 阿托品滴眼液，1 次/d，持续 6 周。实验前后测量豚鼠屈光度和眼球生物参数。 结果：实验开始时 3 组各测量结果差异均无统计学意义。实验起始时各组平均屈光度约为 4.3 D。实验结束时白光组平均屈光度约为 4.84 D，绿光组约为 3.47 D，蓝光组约为 6.19 D，3 组间屈光度差异显著，且 3 组前后屈光度变化量比较差异显著。各组玻璃体腔长度在实验开始约为 3.3 mm，实验结束时白光组约为 3.25 mm，绿光组约为 3.39 mm，蓝光组约为 3.17 mm。此时白光组与绿光组玻璃体腔长度相比差异显著，绿光组与蓝光组相比差异显著，而白光组与蓝光组相比差异无统计学意义。实验结束时 3 组角膜曲率半径、前房深度和晶状体厚度无统计学差异。结论：阿托品通过干预豚鼠玻璃体腔长度的变化而影响单色光对屈光发育的作用，但单色光引起的屈光变化方向不受影响。

bjective: To investigate the effect of atropine on ocular refractive development of guinea pigs in different monochromatic lights. Methods: Twenty-four guinea pigs aged 2 weeks were randomly divided into three groups, which were raised in blue light (BL, 430 nm), green light (GL, 530 nm) and white light (WL, color temperature 5000k), respectively. The two eyes of the guinea pigs in the three groups were treated with 1% atropine eye drops once a day for 6 weeks from the beginning of the experiment. The refraction and ocular biological parameters of the guinea pigs were measured before and after the experiment. Results: At the beginning of the experiment,there was no significant difference in every measurement among the three groups. The average refraction of each group was about 4.3 D at the beginning. At the end of the experiment, the average refraction was approximately 4.84 D in the WL, 3.47 D in the GL, and 6.19 D in the BL. The differences in refraction of the three groups were significant, and the refractive changes of the three groups before and after the experiment were significant. The length of vitreous chamber in each group was approximately 3.3 mm at the beginning, but it was approximately 3.25 mm in the WL, 3.39 mm in the GL and 3.17 mm in the BL at the end of the experiment. At this time, there was significant vitreous difference between the WL and the GL, and between the GL and the BL, but there was no significant difference between the WL and the BL in vitreous length. After the experiment, there was no significant difference in the radius of corneal curvature, depth of anterior chamber and lens thickness among the three groups. Conclusion: The effect of monochromatic light on refractive development is affected by atropine through intervening the vitreous length in guinea pigs, but the direction of refractive change induced by monochromatic light is not influenced.

目的：探讨联合泛格栅光凝、光动力疗法（photodynamic therapy，PDT）、抗血管内皮生长因子（vascular endothelial growth factor，VEGF）药物对大范围湿性年龄相关性黄斑变性（age-related macular degeneration，AMD）的临床疗效，探索对视力较差的湿性 AMD 的更经济的治疗手段。方法：将病灶范围 ≥ 1.5 DD、视力 < 0.3 的 AMD 患者分为试验组与对照组。试验组采用联合治疗，即先采用泛格栅光凝对一个大的脉络膜新生血管（choroidal neovascularization，CNV）病变或多个 CNV 病变的黄斑中心拱环外区域进行直接光凝，再对黄斑中心病变采用 PDT 治疗，最后在 PDT 治疗后 2~3 d 采用玻璃体腔注射抗 VEGF 药物。对照组（VEGF 组）采用标准的 3+prn 抗 VEGF 药物注射治疗。评价治疗前后视力的变化情况、重复治疗次数等。结果：试验组 27 例，治疗次数（1.2±0.47）次；对照组37例，治疗次数（3.4±1.9）次，两组间治疗次数有显著差异，但两组治疗后视力比较无显著差异。结论：采用综合治疗方法，在大大减少治疗次数的前提下，能较好地保存患者的残存视力，具有较大的推广意义。

Objective: To evaluate the clinical efficacy of the combination of pan-macular grid laser, photodynamictherapy (PDT) and anti-vascular endothelial growth factor (VEGF) on a wide range of wet age-related macular degeneration (AMD), and to explore a more economical treatment method for wet AMD with low visual acuity. Methods: Patients with AMD with a range of lesions greater than 1.5 DD and visual acuity less than 0.3 were divided into the experimental group and the control group. In the experimental group, combined treatment was adopted, namely, a large choroidal neovascularization (CNV) lesion or multiple CNV lesions were treated by means of pan-macular grid laser directly in the outer area of the macular central arch, followed by the treatment of macular central lesions by PDT, and finally two to three days after the treatment of PDT, anti-VEGF drugs were injected into the vitreous cavity. In the control group (VEGF group), a standard 3+ prn anti-VEGF medication was administered. The changes in the visual acuity before and after the treatment were evaluated. Results: There were 27 cases in the experimental group, receiving (1.2±0.47) times of treatment on average, and 37 cases in the control received (3.4±1.9) times of treatment on average. Conclusion: The combined treatment can save the patient’s remaining vision and deserves widespread application, on the premise of significantly reducing the number of treatment.

目的：回顾性分析眼科手术前结膜囊细菌培养的阳性菌构成及药物敏感性。方法：选取 2016 年 1 月至 2018 年 1 月在武汉大学人民医院眼科中心住院的 3205 例患者，按照入院疾病不同，分为 3 组行眼分泌物细菌培养，对阳性菌株和药敏结果进行统计分析。结果：3205 例患者眼分泌物培养的阳性率为 8.33% 。其中白内障患者 1435 例，阳性率为 9.13% 。青光眼、孔源性视网膜脱离患者总数分别为 870，900 例，阳性率分别为 10.11% ，5.33% 。孔源性视网膜脱离组与白内障组（P = 0.0008）、青光眼组（P = 0.0002）相比，差异均有统计学意义（均P < 0.05）。白内障与青光眼组相比，差异无统计学意义（P > 0.05）。细菌菌种的阳性株以革兰阳性细菌为多，占 77.90% ，其中表皮葡萄球菌最多，占革兰阳性菌的 66.83% 。药敏检查结果示绝大多数菌株都对红霉素耐药，对万古霉素、庆大霉素、阿米卡星敏感；对妥布霉素及环丙沙星的敏感性稍低。结论：术前常规结膜囊无菌化极为重要，尤其是眼前节手术（如青光眼、白内障）术前。

Objective: To analyze the conjunctival bacterial flora and antibiotic resistance pattern in the patients undergoing surgery. Methods: From January 2016 to 2018, 3 205 patients hospitalized in the Eye Center of People’s Hospital of Wuhan University were divided into three groups according to the diseases. The preoperative conjunctival cultures and antibiotic susceptibility tests of 3 205 eyes were studied retrospectively. Results: Of 3 205 eyes, 267 （8.33%） had positive cultures. The number of cases of cataract, glaucoma and retinal detachment was 1 435, 870 and 900, respectively and the positive rate was 9.13%, 10.11%, 5.33%. Statistical significance was observed in the retinal detachment patients compared with their counterparts with cataract and glaucoma （both P<0.05）. There was no statistically significant difference between the cataract and glaucoma groups （P>0.05）. Grampositive bacterium （G+） （77.90%） was the most common bacterial isolate, mainly staphylococcus epidermidis （66.83%）. Most of the strains were resistant to erythromycin, sensitive to vancomycin, gentamicin and amikacin.The sensitivity of tobramycin and ciprofloxacin was slightly lower. Conclusion: It is of significance to make preoperative conjunctival preparation, especially glaucoma and cataract patients.

目的：探讨对伴有角膜散光的单纯白内障患者行白内障超声乳化联合植入 Toric 人工晶状体后，患者的视力、残余散光、人工晶状体偏转度等情况。方法：采用回顾性分析研究方法。选取 2015 年 12 月至 2017 年 6 月于解放军南京总医院行白内障超声乳化联合散光纠正型人工晶状体植入术的 45 例患者，术眼 47 只。分别测量患者术前的裸眼视力、最佳矫正视力、角膜散光度数以及手术后 3 个月的裸眼视力、最佳矫正视力、残余散光度数、人工晶状体偏移度数等。结果：47 例眼均手术成功。术前患者的裸眼视力为 0.71±0.33 （logMAR），最佳矫正视力为 0.44±0.34 ；术后 3 个月，患者裸眼视力为 0.25±0.17 （logMAR），最佳矫正视力为 0.17±0.16 （logMAR），差异有统计学意义（P  < 0.01）。术前患者角膜散光为（2.82±0.73）D ；术后 3 个月，患者的残余散光度数为（0.41±0.26）D ，较术前明显降低，差异有统计学意义（P < 0.05）。术后 3 个月，患者人工晶状体轴向的偏转度为（3.18±2.06）° 。结论：使用 Toric 人工晶状体治疗伴有角膜散光的白内障安全有效，术后可明显提高患者术后裸眼视力，术后残余散光度数小，可提高患者视觉质量。

Objective: To explore the vision, astigmatism, intraocular lens deflection and visual quality of cataract patients with corneal astigmatism after cataract phacoemulsification combined with Toric intraocular lens implantation. Methods: A retrospective systematic study method was used. From December 2015 to June 2017, a total of 45 patients （47 eyes） underwent cataract phacoemulsification combined with Toric intraocular lens implantation in Nanjing General Hospital. Uncorrected visual acuity （UCVA）, best corrected visual acuity （BCVA） and astigmatism were measured before and 3 months after the operation. The intraocular lens axial was measured at 3 months after operation. Results: The surgery was successfully performed in 47 patients. The UCVA before operation was 0.71±0.33 （logMAR）, the BCVA was 0.44±0.34 （logMAR）; at 3 months after the operation, the UCVA was 0.25±0.17 （logMAR）, the BCVA was 0.17±0.16 （logMAR）, and the difference was statistically significant （P<0.01）. The astigmatism before operation was （2.82±0.73） D. The residual astigmatism at 3 months after operation was （0.41±0.26） D, which was significantly lower than that before operation （P<0.05）; at 3 months after the operation, the axial deflection of the intraocular lens was （3.18±2.06）°. Conclusion: It is safe and effective to treat cataract patients with corneal astigmatism with Toric intraocular lens. After operation, it can significantly improve postoperative visual acuity and residual astigmatism of patients.

     【编者按】2019 国际眼科论坛：人工智能与人工视觉 （2019 IOF-AIAV） 于 2019 年 5 月 24~26 日在深圳喜来登酒店成功举行。本次会议由亚非眼科学会、广东省医学会主办，中山大学中山眼科中心、深圳市眼科医院合办。现任亚非眼科学会主席吴乐正教授担任大会主席。来自中国、埃及、新加坡、韩国、美国等 14 个国家和地区的专家们出席了本次会议，围绕人工智能在眼科的应用，从人工智能与致盲眼病诊疗、医学影像及技术等多个方面展开学术交流与探讨。会议期间，我们有幸邀请到了吴乐正教授进行简单的采访与分享。

     编者按：2019 国际眼科论坛：人工智能与人工视觉 （IOF-AIAV） 于 2019 年 5 月 24 至 26 日在深圳圆满举行。本次论坛以“人工智能与人工视觉”为主题，邀请来自新加坡、韩国、印度、埃及、摩洛哥、突尼斯、巴基斯坦以及香港和台湾等亚非国家和地区的眼科领域的优秀专家学者，就人工智能的应用、眼科博览、人工智能与医疗、眼科大数据和智能医疗、人工智能与影像分析、人工智能与青光眼以及人工视觉等专题进行交流与分享。

     编者按：2019 年 5 月 24 至 26 日，由亚非眼科学会、广东省医学会主办，中山大学中山眼科中心、深圳市眼科医院共同合办的“2019 国际眼科论坛：人工智能与人工视觉 （IOF-AIAV）”在深圳喜来登酒店顺利召开。本次论坛广邀国内外眼科和人工智能领域顶尖的专家学者一同交流探讨人工智能与眼科学的发展。会后，AME 出版社有幸邀请到苏国辉教授接受专访，苏教授就近来备受关注的光疗抗抑郁的神经机制、视神经再生以及人工智能在眼科学中的应用等话题发表个人看法。

目的：探讨泪小管断裂吻合手术影响因素，提高泪小管断裂吻合手术成功率。方法：选择齐齐哈尔市五官医院眼科治疗的泪小管断裂患者 126 例为研究对象，进行术前评估，术后总结分析吻合手术的影响因素及经验。结果：患者均一次性吻合成功，术后治愈 107 例，好转 14 例，无效 5 例，总有效率为 96.03% ；3 例术后泪小管豁裂，2 例术后 1 周内泪道支撑管脱落，二期行泪小管修复手术及 RS 型泪道扩张引流管再次置入后均治愈。结论：泪小管断裂吻合手术前充分分析病情，术中吻合断裂的泪小管、正确处理眼睑裂伤口，加强围手术期护理均有利于提高手术成功率。

Objective: To investigate the influencing factors of anastomosis of lacrimal canaliculi and to improve the success rate of anastomosis. Methods: A total of 126 cases of lacrimal canaliculus fracture treated in Qiqihar Wuguan Hospital were selected, and the preoperative evaluation was carried out. The factors affecting the anastomosis and the operation experience were summarized and analyzed. Results: All cases were anastomosed successfully, 107 cases were cured, 14 cases were improved, 5 cases were not effectively treated and the total effective rate was 96.03%. Three patients suffered from postoperative lacrimal canaliculus laceration, two of them lost the lacrimal duct support tube within 1 week after surgery, which were cured after repeated lacrimal canaliculus anastomosis and the placement of the RS lacrimal duct drainage tube. Conclusion: Comprehensive analysis of lacrimal canaliculus fracture anastomosis before operation, anastomosis of tear canaliculus, effective treatment of eyelid cleft wound and strengthening perioperative nursing are beneficial to improve the success rate of operation.

专栏导读：眼健康是国民健康的重要组成部分。随着我国经济社会的快速发展和眼科医疗卫生事业的快速发展，人民群众对眼健康的需求不断提高。推进眼健康事业，进一步提高人民群众的眼健康水平，是我们义不容辞的责任。结合当前我国眼病防治工作现状，本刊增设“眼健康”专栏，基于中山大学中山眼科中心的传播平台，筛选出较高质量的眼健康科普文章，以实现更大范围的眼健康教育与科学传播。

准妈妈们全身器官都会因为妊娠而发生变化，眼睛当然也不例外。妊娠期眼部的变化大部分是生理性的、无害的；但有些变化是病理性的，如高血压相关视网膜病变，可能是先兆子痫的征兆。笔者总结在孕期中准妈妈们的眼部变化，对如何区分生理性变化和病理性变化进行合理指导，以利于及时制定个体化的治疗或预防方案。

Pregnancy leads to physiological adaptations of the various maternal organs and systems, including the eyes. Most ocular changes in pregnancy are harmless. Some changes, however, are pathological changes and serious, such as retinal effects of hypertension, which can be a sign of pre-eclampsia. We summarize the physiological and pathological ocular changes during pregnancy, and provide reasonable guidance on how to discriminate pathological eye disease from physiological ocular changes to establish an individualized treatment or preventive plan.

目的：观察绷带型角膜接触镜在滞留型铁质角膜异物取出术后的临床疗效。方法：对角膜深层异物取出术后患者 105 例 105 眼，随机分为戴镜组与对照组，两组均为滞留型角膜异物，实施角膜异物取出术，比较两组患者术后 1，3，7 d 的眼部疼痛程度及术后 7 d 角膜上皮愈合情况。结果：术后 1，3，7 d ，两组患者眼部疼痛程度评分差异有统计学意义（P < 0.05）；术后 7 d 两组患者角膜上皮缺损情况差异有统计学意义（P < 0.05）。无感染患者。结论：配戴绷带型角膜接触镜能有效缓解滞留型角膜异物取出术后患者的眼部刺激症状，加速术后角膜创面修复。

Objective: To investigate the effects of bandage contact lenses on corneal irritation and wound healing after the removal of delayed corneal iron foreign body. Methods: A total of 105 patients （105 eyes） with delayed removal of corneal iron foreign body were divided into two groups. Patients in both groups received the removal of corneal foreign body. Patients in group 1 wore bandage contact lenses after surgery, and their counterparts in group 2 did not receive any further treatment after surgery except eye drops. The differences in eye irritation （at 1, 3 and 7 d） and corneal epithelial healing （at 7 d） were observed between two groups. Results: The mean pain score was significantly lower in group 1 than that in group 2 at 1, 3 and 7 d after surgery （all P<0.05）. The rate of complete corneal epithelial healing at 7 d was significantly higher in group 1 than that in group 2 （P<0.05）. Conclusion: Bandage contact lenses can accelerate the recovery of corneal wounds, improve the healthcare efficiency and effectively alleviate eye irritation.