Clinical Trials and Clinical Trial Registration

Eye Science adheres strictly to international guidelines regarding clinical trials and clinical trial registration. We define a clinical trial as any research that prospectively assigns human participants to one or more health-related interventions to evaluate the effects on health outcomes.

To ensure transparency and reproducibility of clinical trials, our policy requires that all manuscripts related to clinical trials be accompanied by the original trial protocol, a complete statistical analysis plan, and any amendments made to the protocol and/or plan.

We recommend that all prospective clinical trials and observational studies be registered on recognized trial registration platforms. Registration ensures the traceability of research and helps prevent unnecessary duplication and selective reporting. Please provide detailed clinical trial registration information in the methods section of your manuscript, including the registration website and trial number. For example, you may register your trial on the International Clinical Trials Registry Platform at http://www.clinicaltrials.gov, the International Standard Randomized Controlled Trial Number registry at http://www.controlled-trials.com, or the Chinese Clinical Trial Registry at https://www.chictr.org.cn/.

Compliance with the CONSORT (Consolidated Standards of Reporting Trials) guidelines is a fundamental requirement for the submission of clinical trial reports. All clinical trial reports should include the relevant CONSORT flow diagram and checklist. For independent sub-analyses conducted on the same population as the original trial, the original trial’s report may be cited without resubmitting the flow diagram and checklist. However, if the sub-analysis focuses on a specific subset of patients, we recommend providing the corresponding flow diagram and checklist to enhance the completeness and transparency of the report.