目的：探讨正常成年 SD 大鼠的明视视网膜电图（Electroretinogram，ERG）特征。

方法：选取正常 9～12 周 SD 大鼠 60 只，使用罗兰视觉电生理仪记录大鼠右眼的明视闪光 ERG。使用 SPSS 统计分析 a 波、b 波和明视负波反应（Photopic negative response，PhNR）的隐含期和振幅。比较雄性和雌性 SD 大鼠明视 ERG 特征。

结果：每只 SD 大鼠均能记录到稳定的 a 波、b 波和 PhNR，其中 a 波的隐含期和 PhNR 的隐含期及振幅均符合正态分布，而其余指标均不符合正态分布。PhNR 的隐含期为 124.6±8.5 ms，其变异系数最小（0.07）。PhNR 的振幅为（11.3±4.2）μV，变异系数为 0.37。雄性和雌性 SD 大鼠明视 ERG 的各反应波之间无显著差异。

结论：在正常成年 SD 大鼠，明视闪光 ERG 是一项客观评价大鼠明视状态下视网膜功能的手段，PhNR 可以作为一项稳定的评价内层视网膜功能的指标。

Purpose: To study the characteristics of photopic flash electroretinogram (ERG) in normal adult SD rats.

Methods: Sixty normal adult SD rats aged 9 to 12 weeks old were enrolled in this study. Photopic flash ERG was recorded from these 60 SD rats. The results were analyzed with SPSS.

Results: Stable a, b and PhNR waves could be recorded in each rat. The implicit time of a wave, implicit time and amplitude of PhNR fit normal distribution. The implicit time of PhNR was (124.6 ± 8.5) ms with the smallest coefficient of variation of 0.07. The amplitude of PhNR was (11.3 ± 4.2) μV and the coefficient of variation was 0.37. There was no difference between the results of female and male rats.

Conclusion: Photopic flash ERG is an objective method in evaluating the retinal function in rats and PhNR can be used as a sensitive index of inner retinal function. 

目的：探讨基质金属蛋白酶-3(matrix metalloproteinases-3，MMP-3)基因多态位点与承德地区人群2型糖尿病视网膜病变的遗传易感性的关系。方法：应用病例对照研究方法，选取195例糖尿病视网膜病变患者(DR组)，其中非增殖性糖尿病视网膜病变(non-proliferative diabetic retinopathy，NPDR)组(n=152)和增殖性糖尿病视网膜病变(proliferative diabetic retinopathy，PDR)组(n=43)，205例单纯糖尿病患者(DM组)和261例正常对照组(Control组)，采用限制性片段长度多态性(restrictive fragment length polymorphism，RFLP)-聚合酶链反应(polymerase chain reaction，PCR)方法检测MMP-3的基因多态性。结果：MMP-3-1171 5A/6A的等位基因及基因型频率分布在Control组，DM组和DR组之间差异无显著性(P=0.474和P=0.407)。MMP-3-1171 5A/6A的等位基因及基因型频率分布在NPDR和PDR组之间差异无显著性(P=0.724和P=0.820)。结论：MMP-3-1171 5A/6A基因多态性与2型糖尿病视网膜病变的遗传易感性无关。

目的：探讨基质金属蛋白酶-3(matrix metalloproteinases-3，MMP-3)基因多态位点与承德地区人群2型糖尿病视网膜病变的遗传易感性的关系。方法：应用病例对照研究方法，选取195例糖尿病视网膜病变患者(DR组)，其中非增殖性糖尿病视网膜病变(non-proliferative diabetic retinopathy，NPDR)组(n=152)和增殖性糖尿病视网膜病变(proliferative diabetic retinopathy，PDR)组(n=43)，205例单纯糖尿病患者(DM组)和261例正常对照组(Control组)，采用限制性片段长度多态性(restrictive fragment length polymorphism，RFLP)-聚合酶链反应(polymerase chain reaction，PCR)方法检测MMP-3的基因多态性。结果：MMP-3-1171 5A/6A的等位基因及基因型频率分布在Control组，DM组和DR组之间差异无显著性(P=0.474和P=0.407)。MMP-3-1171 5A/6A的等位基因及基因型频率分布在NPDR和PDR组之间差异无显著性(P=0.724和P=0.820)。结论：MMP-3-1171 5A/6A基因多态性与2型糖尿病视网膜病变的遗传易感性无关。

Background: The aim of this study was to assess the health literacy of adult Vietnamese population in relation to common eye conditions and identify factors associated with respondents never having had an eye examination.

Methods: Four hundred households from two districts of Ba Ria-Vung Tau (BRVT) province were selected by multistage cluster random sampling. One adult from each household was administered a pre-tested knowledge, attitude and practices toward eye health questionnaire. Chi-square test and logistic regression were used for statistical analysis.

Results: Of the 400 subjects interviewed (mean age: 51.5±14.5 years; range, 30–90 years), 53.5% reported never having had an eye examination and 38.0% had spectacles. Awareness of eye conditions ranged from 7.0% for glaucoma to 52.8% for red eye. Low awareness of these conditions was significantly associated with rural habitation (odds ratio ranged from 1.65 to 2.78), lower educational attainment (odds ratio ranged from 1.78 to 2.59) and non-spectacle wear (odds ratio ranged from 1.88 to 4.55). Significant barriers to eye examination included lower educational attainment, reported absence of eye problems, non-spectacle wear, lack of affordability, and lack of health insurance.

Conclusions: Knowledge of and attitude or practices to eye health is low within the general public in Vietnam, especially among those who have never had an eye examination, are less educated and live in rural areas. Eye health promotion activities are warranted for the population and speciff c factors that influence eye examination visits should be addressed.

Background: The aim of this study was to assess the health literacy of adult Vietnamese population in relation to common eye conditions and identify factors associated with respondents never having had an eye examination.

Methods: Four hundred households from two districts of Ba Ria-Vung Tau (BRVT) province were selected by multistage cluster random sampling. One adult from each household was administered a pre-tested knowledge, attitude and practices toward eye health questionnaire. Chi-square test and logistic regression were used for statistical analysis.

Results: Of the 400 subjects interviewed (mean age: 51.5±14.5 years; range, 30–90 years), 53.5% reported never having had an eye examination and 38.0% had spectacles. Awareness of eye conditions ranged from 7.0% for glaucoma to 52.8% for red eye. Low awareness of these conditions was significantly associated with rural habitation (odds ratio ranged from 1.65 to 2.78), lower educational attainment (odds ratio ranged from 1.78 to 2.59) and non-spectacle wear (odds ratio ranged from 1.88 to 4.55). Significant barriers to eye examination included lower educational attainment, reported absence of eye problems, non-spectacle wear, lack of affordability, and lack of health insurance.

Conclusions: Knowledge of and attitude or practices to eye health is low within the general public in Vietnam, especially among those who have never had an eye examination, are less educated and live in rural areas. Eye health promotion activities are warranted for the population and speciff c factors that influence eye examination visits should be addressed.

Background: To find the changes of macular perimetry (MP) and the correlations between MP and best correct visual acuity (BCVA) in different phases of the acute central serous chorioretinopathy (CSC).

Methods: Twenty-one eyes with acute CSC and their fellow eyes were analysed retrospectively. MP at 2°, 4° and BCVA in the active and resolved phase were collected and analyzed. The differences of these parameters in CSC eyes and fellow eyes were analyzed. Spearman correlation was used for analysis of correlation between MP and BCVA.

Results: From 29 eyes with CSC analysed 27eyes (93.10%) recovered to the previous VA. Compared with the active phase, MP at 2°, 4° and BCVA were significantly improved in the resolved phase(P=0.000, 0.000, 0.000, respectively). MP at 2°, 4° and BCVA of CSC eyes were significantly poor compared with the fellow eyes in the active phase (P=0.000, 0.000, 0.000, respectively). In the resolved phase there was no significant difference between the CSC eyes and fellow eyes (P=0.339, 0.141, 0.161, respectively). BCVA was shown to significantly correlate with MP at 2° in the active phase (ρ=–0.630, P<0.001).

Conclusions: The acute CSC often had a good prognosis both in BCVA and MP. MP can provide an additional objective parameter to evaluate the retinal function changes at macula of acute CSC. 

Background: To find the changes of macular perimetry (MP) and the correlations between MP and best correct visual acuity (BCVA) in different phases of the acute central serous chorioretinopathy (CSC).

Methods: Twenty-one eyes with acute CSC and their fellow eyes were analysed retrospectively. MP at 2°, 4° and BCVA in the active and resolved phase were collected and analyzed. The differences of these parameters in CSC eyes and fellow eyes were analyzed. Spearman correlation was used for analysis of correlation between MP and BCVA.

Results: From 29 eyes with CSC analysed 27eyes (93.10%) recovered to the previous VA. Compared with the active phase, MP at 2°, 4° and BCVA were significantly improved in the resolved phase(P=0.000, 0.000, 0.000, respectively). MP at 2°, 4° and BCVA of CSC eyes were significantly poor compared with the fellow eyes in the active phase (P=0.000, 0.000, 0.000, respectively). In the resolved phase there was no significant difference between the CSC eyes and fellow eyes (P=0.339, 0.141, 0.161, respectively). BCVA was shown to significantly correlate with MP at 2° in the active phase (ρ=–0.630, P<0.001).

Conclusions: The acute CSC often had a good prognosis both in BCVA and MP. MP can provide an additional objective parameter to evaluate the retinal function changes at macula of acute CSC. 

Background: To compare the structural outcome of intravitreal bevacizumab (IVB) and laser treatment for type 1 retinopathy of prematurity (ROP).

Methods: This is a retrospective comparative study. From December 2002 to April 2009, patients with type 1 ROP according to criteria of Early Treatment of Retinopathy of Prematurity (ETROP) study were treated by peripheral retinal diode laser photocoagulation in nearly confluent pattern. From May 2009 to January 2015, we performed IVB for patients with type 1 ROP. The patients were closely followed until disappearance of retinal neovascularization in the laser group and regression of avascular zone in the bevacizumab group. The demographical data, postmenstrual age (PMA) for treatment, and fundus findings were recorded by chart review. The difference between laser and bevacizumab groups was compared by Student t-test and Fisher exact test.

Results: We collected 43 patients (86 eyes) with type 1 ROP, including 30 male and 13 female infants. Their mean gestation age and birth body weight (BBW) were 27.5 weeks and 1,034 gm. Zone I and zone II disease were found in 8 and 35 patients. The mean PMA for treatment was 37.3 weeks. The mean follow-up period was 54.4 months. Laser treatment was administered in 26 patients, and bevacizumab injection for 17 infants. Single session of laser was performed in all patients of laser group without recurrence of retinal neovascularization. Complete regression of ROP was found in 15 infants of bevacizumab group following the first IVB. Four eyes in two patients (2/17, 11.7%) had recurrence of ROP and received additional injections and adjuvant laser treatment. There was no unfavorable anatomical results such as retinal detachment or macular ectopia or complications such as cataract or endophthalmitis in either bevacizumab or laser management.

Conclusions: Laser therapy and IVB were both effective treatments for type 1 ROP to cause favorable anatomical outcomes. Single session of laser ablation in nearly confluent pattern was sufficient for complete regression of ROP in laser group. Single IVB was appropriate for managing most of cases with ROP in bevacizumab group, but a small proportion (nearly one tenth) of them had recurrent episodes requiring adjuvant therapies.

Background: To compare the structural outcome of intravitreal bevacizumab (IVB) and laser treatment for type 1 retinopathy of prematurity (ROP).

Methods: This is a retrospective comparative study. From December 2002 to April 2009, patients with type 1 ROP according to criteria of Early Treatment of Retinopathy of Prematurity (ETROP) study were treated by peripheral retinal diode laser photocoagulation in nearly confluent pattern. From May 2009 to January 2015, we performed IVB for patients with type 1 ROP. The patients were closely followed until disappearance of retinal neovascularization in the laser group and regression of avascular zone in the bevacizumab group. The demographical data, postmenstrual age (PMA) for treatment, and fundus findings were recorded by chart review. The difference between laser and bevacizumab groups was compared by Student t-test and Fisher exact test.

Results: We collected 43 patients (86 eyes) with type 1 ROP, including 30 male and 13 female infants. Their mean gestation age and birth body weight (BBW) were 27.5 weeks and 1,034 gm. Zone I and zone II disease were found in 8 and 35 patients. The mean PMA for treatment was 37.3 weeks. The mean follow-up period was 54.4 months. Laser treatment was administered in 26 patients, and bevacizumab injection for 17 infants. Single session of laser was performed in all patients of laser group without recurrence of retinal neovascularization. Complete regression of ROP was found in 15 infants of bevacizumab group following the first IVB. Four eyes in two patients (2/17, 11.7%) had recurrence of ROP and received additional injections and adjuvant laser treatment. There was no unfavorable anatomical results such as retinal detachment or macular ectopia or complications such as cataract or endophthalmitis in either bevacizumab or laser management.

Conclusions: Laser therapy and IVB were both effective treatments for type 1 ROP to cause favorable anatomical outcomes. Single session of laser ablation in nearly confluent pattern was sufficient for complete regression of ROP in laser group. Single IVB was appropriate for managing most of cases with ROP in bevacizumab group, but a small proportion (nearly one tenth) of them had recurrent episodes requiring adjuvant therapies.

Background: Refractive errors are among the most frequent reasons for demand of eye-care services. Publications on refractive errors prevalence in our country are few. This study has the purpose to assess the prevalence of refractive errors in an adult population of Villa Maria, Córdoba, Argentina.

Methods: The Villa Maria Eye Study is a population-based cross-sectional study conducted in the city of Villa Maria, Córdoba, Argentina from May 2008 to November 2009. Subject’s aged 40+ received a demographic interview and complete ophthalmological exam. Visual acuity was obtained with an ETDRS chart. Cycloplegic auto refraction was performed. The spherical equivalent was highly correlated between right and left eyes, so only data of right eyes are presented. Myopia and hyperopia were defined with a ±0.50 diopters (D) criterion and astigmatism >1 D.

Results: This study included 646 subjects, aged 40 to 90 (mean age: 59.6±10.3 years old). Four hundred and sixty two (71.5%) were females. The mean spherical equivalent was +0.714±2.41 D (range, ?22.00 to +8.25 D) and the power of the cylinder was, on average, ?0.869±0.91 D (range, 0 to ?6.50 D). In this sample, 61.6% subjects were hyperopic, and 13.5% were myopic. Myopia prevalence was lower in men (9.8% versus 14.9%) but this difference among genders was not statistically significant. There were 141 subjects (21.8%) with anisometropia greater than 1 D, and 168 subjects (26.0%) with astigmatism greater than 1 D.

Conclusions: The present study shows the prevalence of cycloplegic refractive errors in an adult population of Argentina. The prevalence of hyperopia was high, while myopia prevalence was very low.

Background: Refractive errors are among the most frequent reasons for demand of eye-care services. Publications on refractive errors prevalence in our country are few. This study has the purpose to assess the prevalence of refractive errors in an adult population of Villa Maria, Córdoba, Argentina.

Methods: The Villa Maria Eye Study is a population-based cross-sectional study conducted in the city of Villa Maria, Córdoba, Argentina from May 2008 to November 2009. Subject’s aged 40+ received a demographic interview and complete ophthalmological exam. Visual acuity was obtained with an ETDRS chart. Cycloplegic auto refraction was performed. The spherical equivalent was highly correlated between right and left eyes, so only data of right eyes are presented. Myopia and hyperopia were defined with a ±0.50 diopters (D) criterion and astigmatism >1 D.

Results: This study included 646 subjects, aged 40 to 90 (mean age: 59.6±10.3 years old). Four hundred and sixty two (71.5%) were females. The mean spherical equivalent was +0.714±2.41 D (range, ?22.00 to +8.25 D) and the power of the cylinder was, on average, ?0.869±0.91 D (range, 0 to ?6.50 D). In this sample, 61.6% subjects were hyperopic, and 13.5% were myopic. Myopia prevalence was lower in men (9.8% versus 14.9%) but this difference among genders was not statistically significant. There were 141 subjects (21.8%) with anisometropia greater than 1 D, and 168 subjects (26.0%) with astigmatism greater than 1 D.

Conclusions: The present study shows the prevalence of cycloplegic refractive errors in an adult population of Argentina. The prevalence of hyperopia was high, while myopia prevalence was very low.